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Ligand-induced activation of the beta-receptor for platelet-derived growth factor (PDGF) induces tyrosine phosphorylation of a number of downstream signaling proteins. In the present study, we used two-dimensional gel electrophoresis to characterize the spectrum of proteins phosphorylated in response to PDGF stimulation in porcine aortic endothelial cells expressing PDGF beta-receptors. Several pr

Denna rapport härstammar från en kollegiegranskning i äldreomsorgen. Tio biståndshandläggare har undersökt sin verksamhet såsom den ter sig i en annan kommun inte så långt därifrån. De skriver kunnigt och engagerat om biståndsbedömning och ställer frågor kring hur detta arbete bör bedrivas. Bengt Ingvad och Christer Neleryd har sammanställt granskningarna. I ett inledande och avslutande kapitel ko

Abstract not available

We describe a new method for analysis of change in glaucomatous visual fields with the object to differentiate between changes caused by glaucoma from those caused by cataract, New pattern deviation change probability maps were developed from a prospectively collected glaucoma material and designed to be sensitive to changes in localized field loss, but to be unaffected by media-induced perimetric

Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730

Increased incidence of prostate cancer has been reported in men exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD acts through the aryl hydrocarbon receptor (AhR), which interacts with the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat that influences its transcriptional activity. We investigated the influence of TCDD on prostate cancer cells (PC-3) and non-tumor p

Objective. To examine psychiatric patients' experience of mechanical restraints and to describe the care the patients received. Background. All around the world, threats and violence perpetrated by patients in psychiatric emergency inpatient units are quite common and are a prevalent factor concerning the application of mechanical restraints, although psychiatric patients' experiences of mechanica

Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B, plays an important role in the regulation of a variety of metabolic processes such as lipolysis and insulin secretion. In this study, the cellular localization and the role of PDE3B in the regulation of triglyceride, cholesterol and glucose

This paper examines the formulation of new porogenic mixtures used to prepare molecularly imprinted polymers (MIPs) in both thin film and bulk monolith formats. Films were cast by using spin coating to spread a pre-polymerization mixture onto a substrate, and rapid curing of the films was achieved with UV photolysis. The use of a low volatility solvent in combination with a linear polymer porogen

To study the importance of estradiol concentrations in which tumors are growing to progression of tumor growth and cell kinetics, we have used a human tumor-nude mice model. In this model a human endometrial adenocarcinoma with estradiol independent but estradiol-responsive growth phenotype (i.e. the tumor was capable of growing in absence of estradiol but its growth could be stimulated by estradi

Moraxella catarrhalis causes respiratory tract infections in children and in adults with chronic obstructive pulmonary disease. It is often isolated as a copathogen with Haemophilus influenzae. The underlying mechanism for this cohabitation is unclear. Here, in clinical specimens from a patient with M. catarrhalis infection, we document that outer membrane vesicles (OMVs) carrying ubiquitous surfa

Popular Abstract in Swedish I denna avhandling behandlas två delvis överlappande teman; inversa problem av tomografisk karaktär samt snabba och noggranna metoder för applicering av faltningsoperatorer. Inom det första temat så studeras det inversa problemet inom Dopplertomografi och för detta ändamål så introduceras Dopplermomenttransformen. Genom att undersöka egenskaperna hos denna transform såThere are two, partially interlaced, themes treated in this thesis; inverse problems of tomographic type and fast and accurate methods for the application of convolution operators. Regarding the first theme, the inverse problem of Doppler tomography is considered and the Doppler moment transform is introduced for that purpose. By investigating the properties of the transform, we prove results reg

A numerical model, called MsDiff (Multi-Species DIFFusion), based on a finite difference method and on the Nernst-Planck relation has been developed. The concentration profiles for several species (i.e., Cl-, Na+, K+ and OH-), the flux and the potential profile are computed. The simulations allow having a better understanding about the phenomena involved during the transport of different ions into