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The role of a split injection strategy in the mixture formation and combustion of diesel spray: A large-eddy simulation

The role of a split injection in the mixture formation and combustion characteristics of a diesel spray in an engine-like condition is investigated. We use large-eddy simulations with finite rate chemistry in order to identify the main controlling mechanism that can potentially improve the mixture quality and reduces the combustion emissions. It is shown that the primary effect of the split inject

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes

Purpose: Diabetic retinopathy is the most common eye complication in patients with diabetes. The purpose of this study is to identify genetic factors contributing to severe diabetic retinopathy. Methods: A genome-wide association approach was applied. In the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) datasets, cases of severe diabetic retinopathy were defined as type 2 d

Tundra landscape heterogeneity, not interannual variability, controls the decadal regional carbon balance in the Western Russian Arctic

Across the Arctic, the net ecosystem carbon (C) balance of tundra ecosystems is highly uncertain due to substantial temporal variability of C fluxes and to landscape heterogeneity. We modeled both carbon dioxide (CO2) and methane (CH4) fluxes for the dominant land cover types in a ~100-km2 sub-Arctic tundra region in northeast European Russia for the period of 2006–2015 using process-based biogeoc

Toward developing consensus on family-centred care : An international descriptive study and discussion

Nurses around the world have described family-centred care (FCC) in various ways. With limited evidence regarding its implementation and with dissent among professionals regarding outcomes that are amorphously defined across age groups, systems and global settings, a group of children’s nursing experts from around the world collaborated to seek clarification of the terms, deconstruct the elements

Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses

Mutated proteins arising from somatic mutations in tumors are promising targets for cancer immunotherapy. They represent true tumor-specific antigens (TSAs) as they are exclusively expressed in tumors, reduce the risk of autoimmunity and are more likely to overcome tolerance compared to wild-type (wt) sequences. Hence, we designed a panel of long peptides (LPs, 28–35 aa) comprising driver gene mut

Retrospective Artifact Elimination in MEGA-PRESS using a Correlation Approach

PurposeTo develop a method for retrospective artifact elimination of MRS data. This retrospective method was based on an approach that combines jackknife analyses with the correlation of spectral windows, and therefore termed “JKC.”MethodsTwelve healthy volunteers performed 3 separate measurement protocols using a 3T MR system. One protocol consisted of 2 cerebellar MEGA‐PRESS measurements: 1 refe

WAVELET NOISE REDUCTION AND VASCULAR WATER TRANSPORT MODELLING : APPLICATIONS TO DIFFUSION AND PERFUSION MRI

Avbildning med hjälp av magnetresonans (MR) är en teknik som används i klinisk diagnostik för att upptäcka och karakterisera en rad sjukdomstillstånd. Metoden baseras på en kombination av statiskt magnetfält, magnetfältsgradienter och pulsade radiofrekventa elektromagnetiska fält i en magnetkamera för avbildning av form och struktur (morfologi) samt vissa funktioner hos olika organ i kroppen.DiffuMagnetic resonance imaging (MRI) is a powerful medical imaging technique, used to detect and characterise a range of diseases and conditions. It is based on the use of a strong static magnetic field in combination with magnetic field gradients and pulsed radiofrequency electromagnetic fields to visualise various organs and structures in the body according to their morphology or function.Diffusion

Enzymatic synthesis and polymerization of isosorbide-based monomethacrylates for high-Tg plastics

Isosorbide is a stiff bicyclic diol derived from glycose-based polysaccharides, and is thus an attractive building block for novel rigid bioplastics. In the present work a highly regioselective biocatalytic approach for the synthesis of isosorbide 5-methacrylate was developed. The Lipozyme RM IM (Rhizomucor miehei lipase) catalyzed process is straightforward, easily scalable and chromatography-fre

Public procurement for innovation to help meet societal challenges : A review and case study

Public procurement for innovation (PPI) is a powerful, underutilized demand-side innovation policy instrument. How this instrument can contribute to meeting societal challenges, which require goaloriented transformation of socio-technical systems, remains unclear and is explored in this article. This article draws on the transitions and PPI literature to propose transformative processes to which P

The factor analytical method for interactive effects dynamic panel models with moving average errors

The estimation of dynamic panel data models with interactive effects and moving average errors is considered. This is accomplished by making an extension to the factor analytical (FA) estimator which was originally designed for dynamic panels with fixed effects only and serially uncorrelated errors. The results show that the additional allowances have no effect on the asymptotic properties of the

Numerical and experimental studies of irregular-shape biomass particle motions in turbulent flows

This paper discusses numerical and experimental studies of biomass micro scale particles motion in turbulent flows. The biomass micro size particles are extremely anisotropic and typically of irregular shape with sizes varying between 200–6000 μm in length and 125–1400 μm in diameter. Four different types of biomass micro size particles from different sources are applied. Ten different numerical m

Climate change perspectives and adaptation strategies of business enterprises : A case study from Italy

The purpose of the paper is to present empirical evidence on how to develop climate-resilient business enterprises under the auspices of an industrial park management. This was facilitated through the collective mapping of climate adaptation strategies corresponding to the identified business risks exacerbated by climate events directly experienced in the shared territory. The cluster approach att