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Wear mechanisms of silicon carbide-whisker-reinforced alumina (Al2O3-SiCw) cutting tools when high-speed machining aged Alloy 718

The paper is aimed at the identification and characterization of wear mechanisms of SiC whisker-reinforced alumina when turning aged Alloy 718 under different cutting conditions and when machining dry and with coolant. Secondary and backscatter electron microscopy accompanied by focus ion beam milling and EDX techniques were used for analysis of worn-out tools. Notch wear on the major cutting edge

Future moisture loads for building facades in Sweden: Climate change and wind-driven rain

This work investigates the prospective impacts of climate change on wind-driven rain (WDR) and walls through simulating the hygrothermal performance of rain screen of common vertical wall constructions for the climatic conditions of Gothenburg in Sweden. While a substantial amount of work has been done on the impact of climate change on the thermal performance of buildings, this paper studies its

Nationwide population-based study on 30-day mortality after radical prostatectomy in Sweden

Objective. The incidence of prostate cancer in Sweden is increasing rapidly, as is treatment with curative intent. Radical prostatectomy (RP) is currently commonly performed, either within or outside large high-volume centres. The aim of this study was to assess the 30-day mortality rate after RP in Sweden. Material and methods. In this nationwide population-based study, all men diagnosed with loc

Detection of high-velocity material from the wind-wind collision zone of Eta Carinae across the 2009.0 periastron passage

We report near-infrared spectroscopic observations of the Eta Carinae massive binary system during 2008-2009 using the CRIRES spectrograph mounted on the 8m UT 1 Very Large Telescope (VLT Antu). We detect a strong, broad absorption wing in He I lambda 10833 extending up to -1900 km s(-1) across the 2009.0 spectroscopic event. Analysis of archival Hubble Space Telescope/Space Telescope Imaging Spec

Protein loop compaction and the origin of the effect of arginine and glutamic acid mixtures on solubility, stability and transient oligomerization of proteins

Addition of a 50 mM mixture of l-arginine and l-glutamic acid (RE) is extensively used to improve protein solubility and stability, although the origin of the effect is not well understood. We present Small Angle X-ray Scattering (SAXS) and Nuclear Magnetic Resonance (NMR) results showing that RE induces protein compaction by collapsing flexible loops on the protein core. This is suggested to be a

The Bioeconomy in Europe: An Overview

A bioeconomy can be defined as an economy where the basic building blocks for materials, chemicals and energy are derived from renewable biological resources. This paper provides an overview of the bioeconomy in Europe, examining it from a policy framework and concept perspective. The role of bioenergy in the bioeconomy is discussed particularly through biofuels for transport and biorefineries. Th

I gränslandet mellan genotyp och fenotyp : motsägelser i samband med prediktiv genetisk testning

Utvecklingen inom genetiken har möjliggjort att prediktiva genetiska tester kan utföras för ett antal mer eller mindre svåra sjukdomstillstånd. Det innebär att individer kan få reda på att de är bärare av ett sjukdomsanlag innan detta anlag ger upphov till konkreta och klara symptom. I spåren av dessa test uppstår ett gränsland mellan vad de genetiska testresultaten visar och uppkomsten av tydliga

The liquid drop model applied to the designer´s dilemma of "getting under the skin" of old users

Instead of discussing existing design methods that aim at bridging or annihilating gaps between users and designers, we want to highlight an approach for designers that helps us increase reflexivity of what is beyond our grasp when interacting with users. The first steps are to become aware of the gaps, identify them, and then manage them. This emphasises and makes visible to both parties the exis

Structural and functional consequences of buserelin-induced enteric neuropathy in rat

Background: Women treated with gonadotropin-releasing hormone (GnRH) analogs may develop enteric neuropathy and dysmotility. Administration of a GnRH analog to rats leads to similar degenerative neuropathy and ganglioneuritis. The aim of this study on rat was to evaluate the early GnRH-induced enteric neuropathy in terms of distribution of neuronal subpopulations and gastrointestinal (GI) function

Clinical evaluation of wireless inductive tongue computer interface for control of computers and assistive devices

Typing performance of a full alphabet keyboard and a joystick type of mouse (with on-screen keyboard) provided by a wireless integrated tongue control system (TCS) has been investigated. The speed and accuracy have been measured in a form of a throughput defining the true correct words per minute [cwpm]. Training character sequences were typed in a dedicated interface that provided visual feedback

Study on aggregation behavior of low density lipoprotein in hen egg yolk plasma by asymmetrical flow field-flow fractionation coupled with multiple detectors.

In this study, asymmetrical flow field-flow fractionation (AF4) coupled online with UV, multiangle light scattering (MALS), and fluorescence (FS) detectors (AF4-UV-MALS-FS) was employed for separation and characterization of egg yolk plasma. AF4 provided separation of three major components of the egg yolk plasma i.e. soluble proteins, low density lipoproteins (LDL) and their aggregates, based on

Emerging pharmacotherapies for Parkinson's Disease: Experimental studies in the rat

Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the typical motor symptoms, akinesia/bradykinesia, rigidity and resting tremor. These symptoms are caused by a deficiency of dopamine (DA) in the brain, which depends on degeneration of DA neurons in the substantia nigra. The most effective treatment for PD is the DA precursor, L-DOPA. Unfortunately, within a few years, L-DO

Changes in microbial activities and biomasses over a forest floor gradient in C-to-N ratio

Under chronically elevated N deposition, N retention mainly occur at high soil C-to-N ratio. This may be mediated through soil microbes, such as ectomycorrhizal (EM) fungi, saprotrophic fungi and bacteria, and the aim of this study was to evaluate the relationship between soil microbes and forest floor C-to-N ratios. Soil samples from 33 Norway spruce (Picea abies (L.) H. Karst) forests in Denmark

Roles of protein kinase C in cell death and breast cancer

Popular Abstract in Swedish För att cellerna i kroppen ska fungera krävs det att proteinerna i cellerna beter sig som de ska, dvs att de signalerar på ett korrekt sätt. Det finns en mängd olika signalvägar i en cell och lika många olika mekanismer som styr signalvägarna. Mycket av det som sker i cellen regleras på ett eller annat sätt utifrån cellens genetiska kod som finns i DNA. DNA:t innehållerAberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was studied in a global gene expression analysis. We found that high PKCα levels correlate with poor pro

Can histology solve the riddle of non-functioning electrodes; factors influencing the biocompatibillity of brain machine interfaces.

Neural interfaces hold great promise to become invaluable clinical and diagnostic tools in the near future. However, the biocompatibility and the long-term stability of the implanted interfaces are far from optimized. There are several factors that need to be addressed and standardized when improving the long-term success of an implanted electrode. We have chosen to focus on three key factors when

Control-Quality Optimization for Distributed Embedded Systems with Adaptive Fault Tolerance

In this paper, we propose a design framework for distributed embedded control systems that ensures reliable execution and high quality of control even if some computation nodes fail. When a node fails, the configuration of the underlying distributed system changes and the system must adapt to this new situation by activating tasks at operational nodes. The task mapping as well as schedules and con