Fms-like tyrosine kinase 3 (Flt3) is an important growth factor receptor in hematopoiesis. Gain-of-function mutations of the receptor contribute to the transformation of acute myeloid leukemia (AML). Src-like adaptor protein (SLAP) is an interaction partner of the E3 ubiquitin ligase Cbl that can regulate receptor tyrosine kinases-mediated signal transduction. In this study, we analyzed the role o

Asteroids and Kuiper belt objects are remnant planetesimals from the epoch of planet formation. The first stage of planet formation is the accumulation of dust and ice grains into mm-cm-sized pebbles. These pebbles can clump together through the streaming instability and form gravitationally bound pebble `clouds'. Pebbles inside such a cloud will undergo mutual collisions, dissipating energy into

The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, Such changes can be contributory to a loss of independence in

The possibility of improving the physical quality of extruded fish feed using transglutaminase (TGase) treatment at different stages of the production process was investigated. The addition of TGase to the raw material mix and processing under high and medium moisture conditions significantly increased (p > 0.05) the durability, hardness and elasticity of fish feed pellets. However, the water stab

Energy use and supply are evident issues to consider for a sustainable development, where the economic, social and environmental aspects are all important. In large grid-bound systems, the supply of energy is usually a rather invisible activity and the contacts between household custo-mers and utilities are sometimes only repre-sented through the energy bill. In this thesis, three particular field

Purpose To investigate the association between maternal use of antihypertensives in early pregnancy and delivery outcome, notably infant congenital malformations. Methods A cohort study of 1,418 women who had used antihypertensive drugs in early pregnancy but had no diabetes diagnosis were identified from the Swedish Medical Birth Register. Results There was an excess risk for placental abruption,

Conclusive English 'then' and Swedish 'då' are compared on the basis of a bi-directional translation corpus. The examples are classified into five different uses according to certain formal and contextual criteria. The two words are shown to have obvious functional similarities: in each of the categories distinguished 'then' and 'då' are the preferred translation equivalents of each other. But the

BACKGROUND: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. OBJECTIVE: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investig

Aim: To assess the development of preterm infants from 40 weeks gestational age to 18 months corrected age in order to identify early predictors of later development. Methods: Fifty-one infants were involved. Infant development was assessed at 40 and 44 weeks gestational age with the Brazelton Neonatal Behavioral Assessment Scale and a Self-Regulation Scale and at 3, 6, 10, 18 months corrected age

The objective of the present study was to evaluate a Monte Carlo feature selection (MCFS) and rough set Rosetta pipeline for generating rule-based models as a tool for comprehensive risk estimates for future Alzheimer's disease (AD) in individual patients with mild cognitive impairment (MCI). Risk estimates were generated on the basis of age, gender, Mini-Mental State Examination scores, apolipopr

This study aimed to explore the conditions for nurses' daily patient education work by focusing on managers' way of speaking about the patient education provided by nurses in hospital care. An explorative, qualitative design with a social constructionist perspective was used. Data were collected from three focus group interviews and analysed by means of critical discourse analysis. Discursive prac

Carbon dioxide (CO2) measurement is a fundamental evaluation in a neonatal intensive care unit (NICU), as both low and high values of CO2 might have detrimental effects on neonatal morbidity and mortality. Though measurement of CO2 in the arterial blood gas is the most accurate way to assess the amount of CO2, it requires blood sampling and it does not provide a continuous monitoring of CO2.

Vegetation dynamics during the earliest part of the Holocene (11,250-10,250 cal yr BP) have been reconstructed from a lacustrine sequence on Sandoy, the Faroe Islands, using detailed plant macrofossil and pollen evidence. The plant macrofossils suggest the initial vegetation was sparse herb and shrub tundra, with Salix herbacea and open-ground species, followed by the development of a denser and m

Based on high-resolution spectra obtained during gravitational microlensing events we present a detailed elemental abundance analysis of 32 dwarf and subgiant stars in the Galactic bulge. Combined with the sample of 26 stars from the previous papers in this series, we now have 58 microlensed bulge dwarfs and subgiants that have been homogeneously analysed. The main characteristics of the sample an