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Giant cell arteritis (GCA), a systemic large-vessel vasculitis, is a disease that has been treated with glucocorticoids since 1950. Over the years, several disease-modifying anti-rheumatic drugs have been evaluated as steroid-sparing agents with disappointing results. Tocilizumab, an interleukin-6 inhibitor, has in recent years been approved for the treatment of GCA. It remains uncertain whether t
Digital media have provided new avenues of distribution for serial fiction and created new narrative possibilities for the form, including the widespread use of what Margolin labels "concurrent narration" and Page terms "real-time narration." This form of serial publication, where a story is distributed in installments coterminously with the events being reported, is enabled by the Internet's poss
Halide perovskites are emerging as revolutionary materials for optoelectronics. Their ionic nature and the presence of mobile ionic defects within the crystal structure have a dramatic influence on the operation of thin-film devices such as solar cells, light-emitting diodes, and transistors. Thin films are often polycrystalline and it is still under debate how grain boundaries affect the migratio
We introduce a time adaptive multirate method based on the Dirichlet-Neumann waveform relaxation (DNWR) algorithm for the simulation of two coupled linear heat equations with strong jumps in the material coefficients across the interface. Numerical results are included to illustrate the advantages of the time adaptive approach over the multirate approach and the robustness of the multirate DNWR me
Reliable simulations of flows in real applications involve the task of discretizing both space and time in an accurate and efficient way. To cope with the large semidiscrete systems resulting from a space discretization on appropriate grids, which often include comparatively few very small cells near solid walls for boundary layer resolution, an implicit-explicit time stepping scheme can be the mo
The distal radius fracture is the most common fracture of them all and it affects both men and women of all ages. However, no study had investigated men specifically. The overall aim of this thesis was to comprehensively study adult men with distal radius fracture addressing the bone mass of adult men from working age to the old and in addition, exploring determinants for self-reported outcome and
This paper uses newly collected data from a large-scale census (Catastro de la Ensenada) to investigate the scale and causes of market integration in eighteenth century Spain. We use wheat prices observed in more than 5,200 municipalities to analyse the local spatial dependence of prices. We detect several regional clusters in the centre and coasts but find that these were not integrated with each
This paper describes the diagnostic criteria for presbyvestibulopathy (PVP) by the Classification Committee of the Bárány Society. PVP is defined as a chronic vestibular syndrome characterized by unsteadiness, gait disturbance, and/or recurrent falls in the presence of mild bilateral vestibular deficits, with findings on laboratory tests that are between normal values and thresholds established fo
The substitution of scandium in fullerene single‐molecule magnets (SMMs) DySc2N@C80 and Dy2ScN@C80 by lutetium has been studied to explore the influence of the diamagnetic metal on the SMM performance of dysprosium nitride clusterfullerenes. The use of lutetium led to an improved SMM performance of DyLu2N@C80, which shows a higher blocking temperature of magnetization (TB=9.5 K), longer relaxation
I detta arbete kommer vi att visa några entydighetssatser för Helmholtz' ekvation. Området begränsas av en yta S som är oändlig. Främst kommer satser som visar entydigheten hos material med förluster att tas fram, men för vissa speciella ytor S kan även rent förlustfria medier behandlas.Randvillkoren kommer att vara av Churchills typ eller mot svarande för permeabla medier. Som ett led i beviskedj
A previously developed formalism for calculation of the scattering from a buried inhomogeneity is taken as a starting point for an iterative scheme for treating the influence of a deviation from a flat interface. This deviation can be a hill, or a depression, of finite extent on an otherwise flat surface. Each iteration takes into account all the multiple interactions between the hill and the inho
The T matrix method (also called the "extended boundary condi tion method" or "null field approach") introduced by Waterman, has recently been generalized to interfaces of infinite extent (G. Kristensson and S. Strom, J. Acoust. Soc. Am. 64917936 (1978) and G. Kristensson, Electromagnetic Scattering from Buried Inhomogeneities - a General Three Dimensional Formalism", Rep. 78-42, Inst. of Theoreti
The T-matrix method (also called the "extended boundary condition method" or "null field approach") is a formalism, which applies to scattering of linear classical waves (i.e. acoustic, electromagnetic and elastic waves). The object of this thesis is to extend the T-Matrix formalism to a geometry consisting of twohalf-spaces, one of which contains a three-dimensional inhomogeneity. The two half-sp
Background and objectives: Beans (Phaseolus vulgaris L.) are widely consumed, but the bioaccessibility of their phenolic compounds (PCs) may be affected by different factors. Within this framework, an in vitro gastrointestinal digestion of two bean varieties: “Azufrado” and “Negro Jamapa,” was performed and the bioaccessibility and in vitro release kinetics of PC was evaluated. Mashed beans were p
Exhaled breath temperature has been suggested to reflect airway inflammation, and it would be plausible to measure the peripheral airway temperature as a correlate to peripheral airway inflammation. This study aims to explore the relative peripheral airway temperature in patients with asthma, chronic obstructive pulmonary disease (COPD) or systemic sclerosis (SSc) compared to healthy controls, and
Background: A psychosocial dementia care programme for challenging behaviour (DEMBASE®) was developed in collaboration with a Swedish BPSD-registry team for in-home care services use in Japan. The programme consisted of a web-based tool for the continued assessment of challenging behaviours and interdisciplinary discussion meetings. Effectiveness of the adapted programme was verified through a clu
