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BACKGROUND & AIMS: Liver tight junctions (TJs) establish tissue barriers that isolate bile from the blood circulation. TJP2/ZO-2-inactivating mutations cause progressive cholestatic liver disease in humans. Since the underlying mechanisms remain elusive, we characterized mice with liver-specific inactivation of Tjp2.METHODS: Tjp2 was deleted in hepatocytes, cholangiocytes, or both. Effects on

Peanut (Arachis hypogaea L.) is an important oilseed crop worldwide, and peanut height has been shown to be closely related to yield, therefore a better understanding of the genetic base of plant height-related traits may allow us to have better control of crop yield. Plant height-related traits are quantitative traits that are genetically controlled by many genes, and distinct quantitive trait lo

Purpose: The study aims to explore how concept stores (theoretically) differ from other experience-based retail formats, and hence, how they (practically) contribute to a diversified retail store portfolio. Design/methodology/approach: Case study based on semi-structured, qualitative interviews with seven IKEA retail managers, three industry experts and 26 customers of IKEA concept stores in Londo

The Southern Hemisphere lichen genus Villophora in subfamily Teloschistoideae is analyzed based on DNA sequence data. Six species are described, five of which are new to science: V. darwiniana and V. wallaceana grow on lignum and bark in southern Patagonia and Tierra del Fuego; V. onas and V. patagonica are lichenicolous or saxicolous on rocks in southern Patagonia; V. rimicola is saxicolous in An

A visual environment impaired by e.g. glare can cause eyestrain, visual symptoms and musculoskeletal strain. A Visual Ergonomics Risk Assessment Method (VERAM) consisting of both a subjective questionnaire and an objective risk assessment, have been used at 217 workplaces, mainly computer work. VERAM can be used to examine and prevent deficiencies and increase wellbeing as well as detecting risks

Objective: To assess the psychometric properties of a Norwegian translation of the Tinnitus Handicap Inventory (THI-NOR). Design: A survey was sent by post to patients referred with tinnitus as their main complaint to an audiology department. Patients completed a Norwegian version of the Tinnitus Handicap Inventory (THI-NOR), a Norwegian translation of two revised subscales of the Abbreviated prof

Many African countries face escalating challenges of increasing disaster risk and anticipated impacts of climate change. Although disaster risk reduction (DRR) and climate change adaptation (CCA) are tightly linked and comprising virtually identical practices in vulnerable countries in Southern Africa, research has identified parallel governance structures across the region. This study applied com

In recent years, climate change and the corresponding expected extreme weather conditions have been widely recognized as potential problems. The building industry is taking various actions to achieve sustainable development, implement energy conservation strategies, and provide climate change mitigation. In addition to mitigation, it is crucial to adapt to climate change, and to investigate the po

Surface segregation phenomena dictate core-shell preference of bimetallic nanoparticles and thus play a crucial role in the nanoparticle synthesis and applications. Although it is generally agreed that surface segregation depends on the constituent materials' physical properties, a comprehensive picture of the phenomena on the nanoscale is not yet complete. Here we use a combination of molecular d

Debatt: Med djup oro ser vi dramatiska förändringar med konsekvenser för både människor och djur. Nu behöver vi alla på ett fundamentalt sätt förändra vårt förhållande till havet. Det skriver 78 forskare, som i dag vill uppmärksamma Världshavsdagen och FN:s årtionde för havsforskning för hållbar utveckling.

BackgroundWithin the ambulance service, assessment and referral of patients, especially those with non-urgent conditions, is a difficult and complicated task. Studies indicate that 12 to 20 percent of all patients are subjected to non-conveyance and discharged at the scene. There is lack of knowledge of what characterizes conveyed and non-conveyed patients. The aim of this study was to explore non

Analyzes research and innovation in the European Union against the backdrop of the COVID pandemic, Brexit, global challenges and a changing international landscape.