Proteostas i stamceller
The ubiquitin-proteasomal system (UPS) plays a crucial role in regulating the levels of most cellular proteins. This intricate system involves approximately 5% of coding genes, with substrate specificity ensured by a diverse group of 650 E3 ubiquitin ligases. These E3 ligases precisely transfer ubiquitin to their target proteins through a process known as ubiquitination, which governs essential ce