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Purpose: To identify overuse of methylphenidate and to investigate patterns of overuse in relation to sociodemographic and clinical characteristics.Patients and methods: Swedish national, pharmacy dispensing data were analyzed for all 56,922 individuals aged 6-79 years, who filled a methylphenidate prescription between 2010 and 2011. Overuse was defined as having above 150% days covered by the dis
The principle of self-determination plays a crucial role in contemporary clinical ethics. Somewhat simplified, it states that it is ultimately the patient who should decide whether or not to accept suggested treatment or care. Although the principle is much discussed in the academic literature, one important aspect has been neglected, namely the fact that real-world decision making is temporally e
Wnt-signaling is one of the most abundant pathways involved in processes such as cell-proliferation, -polarity, and -differentiation. Altered Wnt-signaling has been linked with several neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD) as well as with cognitive functions, learning and memory. Particularly, lipoprotein receptor-related protein 5 (LRP5) or LRP6 co
Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a cardiovascular autonomic disorder characterized by orthostatic intolerance and high prevalence among young women. The etiology of POTS is uncertain, though autoimmunity and inflammation may play an important role. We aimed to identify novel inflammatory biomarkers associated with POTS. Methods and Results: In the Syncope Study of Un
The basic structure of classical density functional theory (DFT) is reviewed from a rather general perspective. The treatment is then specialized to ionic solutions, describing the various possible extensions beyond the Poisson–Boltzmann level, that DFT offers, such as excluded volume effects, non-electrostatic interactions, connectivity (polymers) and ion correlations. The last effects are discus
Att kunna cykla ses som närmast självklart i Sverige. Den som inte kan avviker från normen och från föreställningen om vilka kunskaper och kompetenser en vuxen människa förväntas ha. Att inte kunna cykla blir också ett problem för individen som riskerar att begränsas och utestängas. Intresset för cykelkurser är därför stort. I denna rapport om Cykelfrämjandets projekt Frihet på cykel undersöks för
Distributing sexual content has historically been more strictly regulated in Finland than in Denmark or Sweden. Airing Emmanuelle (1974), a French softcore erotic film by Jaeckin, on Finnish television in 1987 was shocking and front-page news. The article discusses the public reception of Emmanuelle in 1987 in the context of the commercialization of television in Finland.
This article presents the key findings of a Finnish memory-work project conducted in 2012 on consumer experiences and associations related to pornography. The memory-work material points to a high degree of reflexivity in definitions of pornographic preference as well as to drastic shifts in the ubiquity of pornography from the pre-1990s ‘age of scarcity’ to the current ‘age of plenty.’ At the sam
