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Clinical practice guidelines are ubiquitous and are developed to provide recommendations for the management of many diseases, including chronic obstructive pulmonary disease. The development of these guidelines is burdensome, demanding a significant investment of time and money. In Europe, the majority of countries develop their own national guidelines, despite the potential for overlap or duplica
Background: Vitamin D is crucial for mineralized tissue formation and immunological functions. The purpose of this study was to evaluate the association between vitamin D status and dental status in healthy children with vitamin D supplementation in infancy and at 6 years of age. Method: Eight-year-old children who had participated in a vitamin D intervention project when they were 6 years old wer
We have developed a novel method to study the influence of surface nanotopography on human fibrinogen adsorption at a given surface chemistry. Well-ordered arrays of nanoholes with different diameters down to 45 nm and a depth of 50 nm were fabricated in silicon by electron beam lithography and reactive ion etching. The nanostructured chip was used as a model system to understand the effect of siz
Polycrystalline Cubic Boron Nitride (PCBN) has been considered as the main cutting tool material for hard turning, which has the comparable surface finish quality as grinding, and high efficiency, economical technology in production. It is well known that the abrasiveness of the workpiece have the very important role of the machinability of the materials. Therefore, the tool wear of the PCBN inser
We have studied whether calculations of the binding free energy of small ligands to a protein by the MM/GBSA approach (molecular mechanics combined with generalized Born and surface area solvation) can be sped up by including only a restricted number of atoms close to the ligand. If the protein is truncated before the molecular dynamics (MD) simulations, quite large changes are observed for the ca
Diet-induced obesity and insulin resistance have been linked to changes in bile acid (BA) profiles, which in turn are highly dependent on the dietary composition and activity of the gut microbiota. The objective of the present study was to investigate whether the type and level of fiber had an effect on cecal BA composition when included in low- and high-fat diets. Groups of rats were fed two barl
The overarching objective of this study was to produce a disaggregated SMOS Soil Moisture (SM) product using land surface parameters from a geostationary satellite in a region covering a diverse range of ecosystem types. SEVIRI data at 15 min temporal resolution were used to derive the Temperature and Vegetation Dryness Index (TVDI) that served as SM proxy within the disaggregation process. West A
Purpose: The influence of individual factors on patient-reported outcomes is important in the interpretation of disability and treatment effectiveness. The purpose of this study was to assess how physical impairments, psychosocial factors, and life style habits were associated with neck disability based on the Neck Disability Index (NDI), in patients with cervical radiculopathy scheduled for surge
AIM: The aim of this article is to investigate if children (7-17 years) with frequent episodic tension-type headache (FETTH) or chronic TTH (CTTH) have an altered pain perception compared to healthy controls.METHODS: We applied a pressure of five increasing intensities to m. trapezius and m. temporalis with a Somedic Algometer II. Visual analogue scale-score was rated and area under the curve (AUC
In this study, a phosphorus (P) module containing the biogeochemical P cycle has been developed and integrated into the forest ecosystem model ForSAFE. The model was able to adequately reproduce the measured soil water chemistry, tree biomass (wood and foliage), and the biomass nutrient concentrations at a spruce site in southern Sweden. Both model and measurements indicated that the site showed s
Most proteins have evolved to function optimally in aqueous environments, and the interactions between protein and water therefore play a fundamental role in the stability, dynamics, and function of proteins. Although we understand many details of water, we understand much less about the protein-water interface. In this thesis we use molecular dynamics (MD) simulations to cast light on many struct
Non-Orthogonal Multiple Access (NOMA) for a multi-user single- input single-output (SISO) setup is studied in the power and the frequency domains simultaneously. The problem of sum-bandwidth minimization under perfect channel state information is solved for various combinations of rate requirements and user pairings. In this process, an iterative Tabu-search based algorithm is applied to avoid an
Objective: Needle acupuncture in small children has gained some acceptance in Western medicine. It is controversial, as infants and toddlers are unable to consent to treatment. We aimed to assess its efficacy for treating infantile colic. Design: A systematic review and a blinding-test validation based on individual patient data from randomised controlled trials. Primary end-points were crying tim
Non-Orthogonal Multiple Access (NOMA) is studied under statistical Channel State Information (CSI) and probabilistic constraints. Unlike the conventional power domain only NOMA, the definition of NOMA here considers both the power and the frequency domains simultaneously, where a flat power spectrum is assumed for each UE. This increases the capacity region when compared to the conventional definiti
For a pair of closely located and cooperating user equipments (UEs), a precoder is designed at the base station (BS) which considers the UE cooperation. The UEs collaborate over an out-of-band side-link with a finite capacity. The side-link may be used for interference cancellation (IC) or for relaying decoded symbols. The precoder has two parts, a cooperative part based on channel inversion and a
STUDY DESIGN: This prospective, randomized study compares the efficacy of surgical and conservative treatments in patients with long-lasting cervical radicular pain.OBJECTIVES: To compare the effects of surgery, physiotherapy, and a cervical collar.SUMMARY OF BACKGROUND DATA: There are no previous controlled outcome studies that have compared surgical treatment with nonsurgical treatment of patien
Background: Echolucent carotid plaques have been related to an increased risk of ischemic cerebrovascular events. The aim of the present study was to evaluate whether a new objective ultrasonographic parameter, the statistical geometric feature (SGF), reflecting spottiness of carotid plaques, can be associated with cerebrovascular symptoms and with a rupture-prone plaque phenotype. Methods: The pl
