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Genome-wide association (GWA) studies usually detect common genetic variants with low-to-medium effect sizes. Many contributing variants are not revealed, since they fail to reach significance after strong correction for multiple comparisons. The WTCCC study for hypertension, for example, failed to identify genome-wide significant associations. We hypothesized that genetic variation in genes expre
Background: The large sensitivity, high reproducibility and essentially unlimited dynamic range of real-time PCR to measure gene expression in complex samples provides the opportunity for powerful multivariate and multiway studies of biological phenomena. In multiway studies samples are characterized by their expression profiles to monitor changes over time, effect of treatment, drug dosage etc. H
Background and aims: Acute pancreatitis (AP) is a common condition characterized by premature protease activation, abdominal pain and leakage of pancreatic enzymes to the circulation. Approximately 10% develop systemic inflammation and persistent organ failure. Although persistent organ failure in AP is associated with considerable mortality, no therapies to moderate the disease are at hand. This
We are currently witnessing an enormous interest in psi phenomena as cultural and experiential events, displayed in landmark exhibits throughout the world and discussed from historical and other perspectives. This essay focuses on the various connections between art and psi. We mention how many forbears of parapsychology were artists or had a serious interest in the arts, and discuss how ostensibl
We have studied the conformational dependence of molecular mechanics atomic charges for proteins by calculating the charges fitted to the quantum mechanical (QM) electrostatic potential (ESP) for all atoms in complexes between avidin and seven biotin analogues for 20 snapshots from molecular dynamics simulations. We have studied how various other charge sets reproduce those charges. The QM charges
The topic of this thesis is bioprocess control, more specifically control of industrial-scale microbial fed-batch bioprocesses. Its focus is therefore on methods which are easy to implement in an industrial setting, which gives certain limitations on sensors, actuators and control systems. The main part of the work in the thesis concerns control of the microbial substrate uptake rate by manipulat
We use statistical correlation of palaeomagnetic secular variation (PSV) curves from a varved Holocene lake sediment sequence in west central Sweden (Lake Kälksjön) against those of a Fennoscandian master stack (FENNOSTACK) to correct for an apparent error in the varve chronology. Additional correlation between a lead pollution-derived chronology for the last 2000 years corroborates the PSV result
Habitat selection is an important process that affects the distribution and abundance of organisms, and habitat selection theory is one of the flagships of theoretical ecology. Because of the importance of habitat selection in natural ecosystems and the successful history of the theoretical concepts, it has been Suggested that habitat selection theory can inform decision-making in population monit
Although heavy on labor and equipment, thus not often applied, cryoanalysis of frozen hydrated biological specimens can provide information that better reflects the living state of the organism, compared with analysis in the freeze-dried state. In this paper we report a study where the cryoanalysis facility with cryosectioning capabilities at Materials Research Department, iThemba LABS, South Afri
Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. Methods and results We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholestero
Adsorption of uncharged homopolymers in good and theta solvents onto planar surfaces at various chain flexibility and polymer-surface attraction strengths was investigated by using a coarse-grained bead-spring polymer model and simulation techniques. Equilibrium properties of the interfacial systems were obtained from Monte Carlo simulations by monitoring the bead and polymer density profiles, the
Streptococcus pyogenes is an important human pathogen and surface structures allow it to adhere to, colonize and invade the human host. Proteins containing leucine rich repeats (LRR) have been indentified in mammals, viruses, archaea and several bacterial species. The LRRs are often involved in protein-protein interaction, are typically 20-30 amino acids long and the defining feature of the LRR mo
We perform a minimum distance analysis of a class of two-dimensional intersymbol interference (ISI) channels applicable to multitrack magnetic recording and orthogonal frequency division multiplex transmission systems. Exact minimum distance for a wide class of ISI responses is derived. The fundamental analytical technique is to transform the channel into an equivalent minimum phase channel. The r
Objective. Due to the high incidence of neonatal complications in diabetic pregnancies, the aim of our study was to investigate whether elective cesarean section could prevent adverse neonatal outcome. Design. Population-based study. Setting. Data were extracted from the Swedish Medical Birth Registry. Population. All women (n=13 491) with diabetic pregnancies during the period 1990-2007. Methods.
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Denna artikel analyserar den Europeiska upphovsrättens stigberoende (path dependence) i termer av en rättslig inlåsning oförmögen att anpassa sig till nyare sociala praktiker i ett digitalt samhälle. Artikeln härleder inlåsningen till framförallt tre huvudskäl relaterade till a) transaktionskostnader, b) makt, och c) nyckelmetaforers relation till tankestrukturer. Genom att analysera den moderna e
