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Cannabinoid receptors 1 (CB1) and/or 2 (CB2) are overexpressed in many types of human malignancies including mantle cell lymphoma (MCL). Agonists to CB1 and CB2 promote ceramide de novo synthesis, p38-mitogen-activated protein kinase-dependent activation of caspase-3 and apoptotic cell death in most MCLs. However, in this report we describe that in some MCLs the response to treatment with cannabin
The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet been defined. Two genes under direct control of SOX11 are the class- III β-tubulin gene (TUBB3) in neural cells and the transcription factor
BACKGROUND: Human B lymphocytes can produce leukotriene B4 but the biological function of the 5-lipoxygenase (5-LO) pathway in B cells is unclear. In order to better understand and define the role of 5-LO in B cells, we investigated the expression of 5-LO mRNA and protein in subsets of B cells from human tonsils and different types of B cell lymphoma.RESULTS: Based on RT-PCR and western blot/immun
Endogenous and synthetic cannabinoids exert antiproliferative and proapoptotic effects in various types of cancer and in mantle cell lymphoma (MCL). In this study, we evaluated the expression of cannabinoid receptors type 1 and type 2 (CB1 and CB2) in non-Hodgkin lymphomas of B cell type (n = 62). A majority of the lymphomas expressed higher mRNA levels of CB1 and/or CB2 as compared to reactive ly
För att stötta nyanlända elever i skriftliga uppgifter i bildämnet kan läraren använda sig av cirkelmodellens fyra steg i textframställningen. Genom att gemensamt bygga upp ämneskunskaper, studera den texttyp som ska skrivas och formulera en första text ges eleven bättre möjligheter att klara en individuell skrivuppgift. Andra konkreta redskap som skrivmallar och begreppslistor fungerar också stöt
Matematikämnets texter ställer höga krav på elevernas läskompetens både när det gäller avkodning och förståelse. Detta innebär en extra utmaning för nyanlända elever. Det finns olika exempel på stöttning som kan ge nyanlända elever möjlighet att fördjupa sina ämneskunskaper i matematik samtidigt som de stärker sitt svenska skolspråk och ämnesspråk. Några exempel är lässtrategier före, under och ef
Sverige framhålls ofta som ett föregångsland gällande personlig assistans (PA) och mänskliga rättigheter. Forskning visar dock att bedömningen av rätten till PA styrs av en medicinsk förståelse av funktionshinder och av ekonomiska snarare än funktionshinderpolitiska mål. Nedskärningar har medfört att antalet med statlig assistansersättning har minskat. Syftet med artikeln är att belysa de motstridSweden is often highlighted as a pioneering country in terms of personal assistance (PA) and human rights. However, research shows that the assessment of PA is guided by a medical understanding of disability and by austerity ratherthan by disability policy. Furthermore, the number of people with state-funded PA has decreased. The purpose of the article is to illuminate the contradictions that char
Att vara tydlig och konkret är centrala aspekter i arbetet med formativ bedömning. Läraren behöver kommunicera en tydlig målbild och ge konkret och begriplig respons inte bara efter utan också under arbetets gång för att både visa på styrkor, utmana eleverna och hjälpa dem vidare. Vid kamratrespons är det angeläget att läraren förbereder den språkliga inramningen av responsen, till exempel med hjä
This case study investigates the potentials, greenhouse gas (GHG), and energy performance of forest residue biofuels produced by new and emerging production technologies, which are commercially implemented in Sweden for heavy transport. The biofuel options included are ethanol (ED 95), hydro-processed vegetable oil (HVO), and liquefied biogas (LBG) produced from logging residues in forestry and sa
A life cycle assessment is presented for a current vehicle’s greenhouse gas impact when using a combination of electrification and renewable fuels. Three degrees of electrification are considered: a hybrid electric vehicle, a plug-in hybrid electric vehicle, and a battery-electric vehicle. These are combined with fuels with various degrees of renewable content, representing a fossil fuel, a first-
A widely embraced approach to mitigate the dynamic degradation in low-inertia power systems is to mimic generation response using grid-connected inverters to restore the stiffness of the grid. In this article, we seek to challenge this approach and advocate for a principled design based on a systematic analysis of the performance trade-offs of inverter-based frequency control. With this aim, we pe
Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, small airway remodeling, and emphysema. Airway remodeling in patients with COPD involves both the airway epithelium and the subepithelial extracellular matrix (ECM). However, it is currently unknown how epithelial remodeling in COPD airways depends on the relative influence from inherent defects in the epithelial
Background: The inverse observational association between body mass index (BMI) and lung cancer risk remains unclear. We assessed whether the association is explained by metabolic aberrations, residual confounding, and within-person variability in smoking, and compared against other smoking-related cancers. Methods: We investigated the association between BMI, and its combination with a metabolic
This dissertation is developed against the background of globalisation and the rise of a new type of instrument used to deal with the accompanying developments. These instruments are designated by the present dissertation as global framework agreements (GFAs). They constitute a written compromise, signed between global union federations and multinational enterprises, setting rights-based minimum s
This thesis focuses mainly on the co-integration of vertical nanowiren-type InAs and p-type GaSb MOSFETs on Si (Paper I & II), whereMOVPE grown vertical InAs-GaSb heterostructure nanowires areused for realizing monolithically integrated and co-processed all-III-V CMOS.Utilizing a bottom-up approach based on MOVPE grown nanowires enablesdesign flexibilities, such as in-situ doping and heterostr
