Lipoproteins in blood play an important physiological role transporting cholesterol, lipids and lipid-soluble substances to the different organs of the body. Diseases such as atherosclerosis, cardiovascular disease and stroke are associated with defects in lipoprotein metabolism. For many years, intense research has focused on the role of cholesterol in development of atherosclerosis. Cholesterol

The general aim of the thesis was to contribute to a more evidenced based framework in the surgical treatment of diseases in the gastroesophageal junction (GEJ), by comparing outcome, measured by complication and survival rates, and evaluate different reconstructions regarding long-term symptoms and quality of life (QoL). The GEJ is a poorly defined anatomic area that represents the lower part of

The design and pore distribution of the membrane are important factors in cross-flow membrane emulsification. To determine the effects of hydrodynamics and drop interaction on drop size, drop formation has been studied numerically using computational fluid dynamics (CFD). Oil with a viscosity of 7.0 mPa s was used as the dispersed phase and water was used as the continuous phase. The conditions st

Unlike common engineering materials, living matter can autonomously respond to environmental changes. Living structures can grow stronger, weaker, larger, or smaller within months, weeks, or days as a result of a continuous microstructural turnover and renewal. Hard tissues can adapt by increasing their density and grow strong. Soft tissues can adapt by increasing their volume and grow large. For

New anatomical observations of the holotype skull of Plotosaurus bennisoni from the Maastrichtian Moreno Formation of California, U.S.A., are used as a framework to examine cranial kinesis in derived members of the Mosasaurinae. Enlarged posteromedial flanges of the frontal and extensive lateral contacts of the prefrontal and postorbitofrontal contributed to increased rigidity along the frontopari

The present intervention was designed to investigate whether a 14-week period of regular recreational association football (F) or endurance running (R) has an effect on the risk of falls and bone fractures due to gains in muscle function and volumetric bone mineral density (vBMD). Fifty healthy untrained Danish premenopausal women were randomized into two training groups (F and R) that trained 1.8

Background- This nationwide study sought to determine age- and gender-specific familial risks in siblings hospitalized for venous thromboembolism (VTE). Methods and Results- The Swedish Multigeneration Register on 0- to 75-year-old subjects was linked to the Hospital Discharge Register for the years 1987-2007. Standardized incidence ratios were calculated for individuals whose siblings were hospit

In order to understand ritual in the past, archaeology has long relied on theories developed in other disciplines. While these theories, which often rely on written or oral information, have added many important dimensions to our interpretation of the archaeological record, they have often proven difficult to successfully articulate with the archaeological sources. Moreover, archaeology has tended

This Letter describes a model-independent search for the production of new resonances in photon + jet (gamma + jet) events using 20 fb(-1) of proton-proton LHC data recorded with the ATLAS detector at a centre-of-mass energy of root s = 8 TeV. The gamma + jet mass distribution is compared to a background model fit from data; no significant deviation from the background-only hypothesis is found. Li

Antigen presenting cells (APC) have the ability to present both extra-cellular and intra-cellular antigens via MHC class I molecules to CD8(+) T cells. The cross presentation of extra-cellular antigens is reduced in mice with deficient Antigen Peptide Transporter 1 (TAP1)-dependent MHC class I antigen presentation, and these mice are characterized by a diminished CD8(+) T cell population. We have

Control design is a rich problem which requires a compromise between performance and robustness. This paper explores how filtering of the measured signal influences the undesirable control actions generated by measurement noise, the load disturbance response, and the robustness to process uncertainty. The analysis is condensed to design rules.

Several protein kinase C (PKC) isoforms have been suggested as potential targets for breast cancer therapy. To explore the role for PKC isoforms in processes that facilitates malignant progression and the utility of PKC isoforms as biomarkers in breast cancer, we designed a study where we evaluated the expression of PKCα, δ, and ε in primary breast cancers as well as in breast cancer cell lines. W

We present noble gas analyses of sediment-dispersed extraterrestrial chromite grains recovered from similar to 470 Myr old sediments from two quarries (Hallekis and Thorsberg) and of relict chromites in a coeval fossil meteorite from the Gullhogen quarry, all located ill Southern Sweden. Both the sediment-dispersed grains and the meteorite Gullhogen 001 were generated in the L-chondrite parent bod

Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that short-term treatment with the anti-estrogens tamoxifen or fulvestrant decrease cell proliferation but increase BC stem cell (BCSC) activity through JAG1-NOTCH4 receptor activation both in patient-derived samples and xenograft (PDX) tumors.

Even if outsourcing is a well-researched phenomenon, it can be stated that evaluation studies on IS outsourcing relationships are scarce. From a description of two IS outsourcing relationship cases, a set of les-sons learned are presented. A boundary spanning perspective is then used when evaluating these lessons learned in the client-supplier outsourcing relationships and thereby adding a “new” t

In this paper we employ the news aggregator Google News to demonstrate a strong link between the volatility in the stock market and the amount of news available to market participants. The paper also highlights some other areas, in finance and elsewhere, where news aggregators could be useful.

BACKGROUND: Despite their pivotal roles in colorectal carcinogenesis, the interrelationship and prognostic significance of beta-catenin alterations and microsatellite instability (MSI) in colorectal cancer (CRC) needs to be further clarified. In this paper, we studied the associations between beta-catenin overexpression and MSI status with survival from CRC, and with expression of p21, p27, cyclin