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Secondary mitral regurgitation (MR) occurs despite structurally normal valve apparatus due to an underlying disease of the myocardium leading to disruption of the balance between tethering and closing forces with ensuing failure of leaflet coaptation. In patients with heart failure (HF) and left ventricular dysfunction, secondary MR is independently associated with poor outcome, yet prognostic ben

Atherosclerosis is a lipid-driven, chronic inflammatory disease. In spite of efficient lipid lowering treatments, such as statins and PCSK9 inhibitors, patients, especially those with elevated inflammatory biomarkers, still have a significant residual cardiovascular disease risk. Novel drugs targeting inflammatory mediators are needed to further reduce this residual risk. Agonistic immune checkpoi

Background: Stroke and dementia are interrelated diseases and risk for both increases with age. Even though stroke incidence and age-standardized death rates have decreased due to prevention of stroke risk factors, increased utilization of reperfusion therapies, and other changes in healthcare, the absolute numbers are increasing due to population growth and aging. Objective: To analyze predictors

Thrombocytopenia results from a variety of conditions, including radiation, chemotherapy, autoimmune disease, bone marrow disorders, pathologic conditions associated with surgical procedures, hematopoietic stem cell transplant (HSCT), and hematologic disorders associated with severe aplastic anemia. Immune thrombocytopenia (ITP) is caused by immune reactions that accelerate destruction and reduce

Introduction: Inhibitors develop less frequently in haemophilia B (HB) than haemophilia A (HA). However, when present, the success of tolerization by immune tolerance induction (ITI) therapy is lower and the risk of complications higher. Aim: To evaluate the use and outcome of ITI in patients with HB and inhibitors. Methods: Subjects include singletons or siblings with a current/history of inhibit

Purpose: High-performing imaging and predictive markers are warranted to minimize surgical overtreatment of the axilla in breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Here we have investigated whether axillary ultrasound (AUS) could identify axillary lymph node (ALN) metastasis (ALNM) pre-NACT and post-NACT for BC. The association of tumor, AUS features and mammographic d

By disrupting investment, supply chains and technology diffusion, COVID-19 may harm renewables more than coal, but still weaken coal lock-in in developing countries. To enable new low-carbon energy choices, international flows of low-carbon technology and policy expertise must quickly re-emerge.

Industrial lignin such as kraft lignin is an abundant feedstock for renewable chemicals and materials. In this study, a process was developed for depolymerization of kraft lignin followed by an upgrading separation step and further bioconversion of the obtained monoaromatic compounds to muconic acid. First, industrial kraft lignin, Indulin AT, was processed into a guaiacol-rich stream using base-c

There are fundamental unresolved questions about the nature of the long-run interplay between innovation and economic development processes. This study examines technological transitions in Sweden, 1908-2016, using a new literature-based innovation output indicator for the engineering industry, allowing a mixed-methods approach. The results suggest that waves of innovation have taken place during

Wildfires are expected to increase with warmer climate, which can contribute to the mobility and the resuspension of long-lived and potentially hazardous radionuclides. The release of 137Cs during combustion of dried litter, forest floor organic soil, and peat was investigated in a small-scale experimental set-up. Combustion conditions were varied to simulate different wildfire scenarios, and the

Gadolinium-148 is one of the radionuclides of most concern that will be produced in the tungsten target of the European Spallation Source (ESS), as a by-product of the spallation reaction used by the facility to produce neutrons. Since 148Gd a pure alpha emitter, it is both very radiotoxic and difficult to measure. With its half-life of 75 years, it will remain in the environment for a long time i

PURPOSE: To investigate the patterns of healthcare use (HCU) at the last year of life in persons with osteoarthritis (OA).METHODS: Using linked registers, we identified persons aged≥ 65 years who died during 2003-2014 and were resided in the Skåne region during 5-year prior to death. Among these, we randomly matched decedents with a principal OA diagnosis prior to the last year of life (OA cohort,

This article explores how an East-west inter-church relationship during the Cold War was given multiple meanings. The link that emerged during the late 1970s between Växjö diocese (Church of Sweden) and Pommersche Landeskirche is used to illustrate the case in point. Whereas an Uppsala-based national church leadership saw such connections as efforts to bring peace and reconciliation, the regional

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Dialogic resonance, when speakers reproduce constructions from prior turns, is a compelling type of coordination in everyday conversation. This study takes its starting point in resonance in stance-taking sequences with the aim to account for the interplay between intersubjective motivations and cognitive facilitation in resonance production. It analyzes stance-taking sequences in the London–Lund

We here report on the synthesis and polymerization of nitrile-containing methacrylate monomers, prepared via straightforward nitrilation of the corresponding lignin-inspired aldehyde. The polymethacrylates reached exceptionally high glass transition temperatures (Tg values), i.e., 150, 164, and 238 °C for the 4-hydroxybenzonitrile, vanillonitrile, and syringonitrile derivatives, respectively,

Organizations interact with their stakeholders to a large degree through social media such as Facebook, Instagram, Twitter and YouTube ( Bellucci & Manetti, 2017). There are indications that there is an increase in the use of emotional language in organizations’ external communication in social media over time, since this is thought to generate more stakeholder engagement (Weinryb et al, 2021)