Stress-induced inhibition of protein synthesis initiation : Modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat
Neuronal protein synthesis is severely depressed following stress such as heat-shock, hypoxia, and hypoglycemia. Following reversible cerebral ischemia, protein synthesis is transiently inhibited in ischemia-resistant areas, but persistently depressed in vulnerable brain regions. Eukaryotic initiation factor 2 (elF-2) activity, that is, the formation of the ternary complex elF-2 · GTP · initiator
