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Cartilage oligomeric matrix protein (COMP) and thrombospondin 1 (TSP1) were purified in a native form from normal bovine articular cartilage. The key step in the purification scheme was selective extraction with EDTA-containing buffer. Final separation of these two molecules was achieved by heparin affinity chromatography. Particles viewed by electron microscopy after rotary shadowing and negative

Popular Abstract in Swedish Bakgrunden till den här avhandlingen är att man vill utveckla en ny mammografimetod, som utnyttjar ultraljud. När en tunn stråle av kontinuerligt ultraljud träffar en partikel, till exempel en blodkropp, som rör sig, så uppstår en reflektion. Frekvensen av den reflekterade signalen är inte densamma som för den utsända. Signalen har fått ett så kallat Dopplerskift, där fThe motivation to study the kind of problems appearing in this thesis has been ultrasound measurements of flows, from which velocity spectra along lines can be determined. These velocity spectra can mathematically be described by a new non-linear transform, here called the Doppler Spectral Transform (DST). The Doppler spectral transform has a very rich theory, into which some steps are taken here

Supplementation of a chemically defined medium with amino acids or succinate to improve heterologous xylanase production by a prototrophic Saccharomyces cerevisiae transformant was investigated. The corresponding xylanase production during growth on ethanol in batch culture and in glucose-limited chemostat culture were quantified, as the native ADH2 promoter regulating xylanase expression was dere

Multiconfigurational quantum chemical methods (complete active space self-consistent field (CASSCF)/second-order perturbation theory (CASPT2)) have been used to study the agostic interaction between the metal atom and H(C) in the methylidene metal dihydride complexes H2MCH2, where M is a second row transition metal or the actinide atoms Th or U. The geometry of some of these complexes is highly ir

An improved method of calculating the rate of striation thinning for laminar flow in a static mixer has been developed. The shapes of the objects studied are reconstructed using elliptic Fourier descriptors, allowing discrimination between true changes in shape and noise due to discretization errors. The method also allows one to choose the level of complexity in the objects to be reconstructed wh

The volumetric response of polymer gels on cosolute addition depends on the interaction of the polymer with the cosolute and can be used as a simple and sensitive way of elucidating these interactions. Here we report on DNA networks, prepared by crosslinking double-stranded DNA with ethylene glycol diglycidyl ether (EGDE); these have been investigated with respect to their swelling in aqueous solu

The two themes of this thesis are operator interaction and optimization, primarily with application to complex plants in the process industry. Four important aspects that should be considered in the control system design for such plants are identified; safety, performance, operator interaction and operator acceptance. In particular, operator acceptance is considered as an aspect of major importanc

Exchange-split two-dimensional electronic states at the magnetic Gd(0001) surface change their energy dispersion upon magnetization reversal owing to the Rashba effect. The Rashba parameter is found to be substantially enhanced and to change sign when an epitaxial metal-oxide surface layer is formed. The experimental observations are quantitatively described by ab initio calculations giving a deta

OBJECTIVE - This study was designed to investigate the clinical characteristics of a large type 1 diabetic population and to evaluate the degree of fulfillment of recently updated treatment goals. RESEARCH DESIGN AND METHODS - The Swedish National Diabetes Register was initiated in 1996 as a tool for quality assurance in diabetes care. A1C levels, treatment, and risk factors were analyzed in two c

Ovariectomized virginal rabbits were treated with either estrogen or progesterone for 4 to 6 months. In vitro responses of muscle strips of the bladder and circular urethra were examined. Estrogen resulted in bladder contractions in response to noradrenaline and phenylephrine, whereas these agonists were without effect or evoked weak relaxations in castrated animals (and normals). Estrogen also ca

Dynamic susceptibility-contrast (DSC) MRI requires deconvolution to retrieve the tissue residue function R(t) and the cerebral blood flow (CBF). In this study, deconvolution of time-series data was performed by wavelet-transform-based denoising combined with the Fourier transform (FT). Traditional FT-based deconvolution of noisy data requires frequency-domain filtering, often leading to excessive

The defense against mucosal infections relies on chemokines that recruit inflammatory cells to the mucosa. This study examined if the chemokine response to uro-pathogenic Escherichia coli is influenced by fimbrial expression. The CXC (CXCL1, CXCL5, CXCL8, CXCL9, CXCL10) and CC chemokines (CCL2, CCL3, CCL5) were quantified after in vitro infection of uro-epithelial cells with a fimbriated E. coli p

Popular Abstract in Swedish Från 1980-talet har etiken diskuterats flitigt i samhället. Det har i samband med detta utvecklats etiska kommittéer. Etiska kommittéer är en typ av organ inom företag, branscher, professioner och andra organisationer som handhar etiska frågor och problem. De etiska kommittéerna fungerar rådgivande i etiska frågor, de kan fastställa etiska regler för en organisation ochThis thesis analyses the development of ethics committees from a sociology of law perspective and a social steerage perspective ("social control"). The main question is: Why are ethics committees established? Institutionalised ethics committee is a rather new phenomenon, which has become widely spread in the last 20 years. The study points out the public ethical debate since the 1980s as a major e

This paper is concerned with a new class of graded algebras naturally uniting within a single framework various deformations of the Witt, Virasoro and other Lie algebras based on twisted and deformed derivations, as well as color Lie algebras and Lie superalgebras.

Popular Abstract in Swedish Den sedimentära lagerföljd som bygger upp Gotland avlagrades för drygt 400 miljoner år sedan (under silurperioden) i ett varmt tropiskt innanhav strax söder om ekvatorn. Innanhavet sträckte sig som en vid bukt in över dagens södra Skandinavien, Baltikum och vidare mot sydost, till Ukraina. Avhandlingen behandlar primärt hur sedimentationsmönster utvecklades under cirka The Silurian foreland of Scandinavia included a vast epicontinental carbonate platform system of which the island of Gotland (Sweden) is an erosional remnant. This thesis treats the Late Wenlock succession (Cyrtograptus lundgreni, Pristiograptus dubius parvus, Gothograptus nassa, Colonograptus(?) praedeubeli, and the Co(?) deubeli zones), and emphasises the sedimentology and biostratigraphy of the