Metabolic abnormalities are proposed to contribute to pulmonary arterial as well as right ventricular remodelling in pulmonary arterial hypertension. Among the proposed abnormalities are altered glucose and lipid processing, mitochondrial malfunction, oxidative stress as well as vitamin D and iron abnormalities. In the present study, we investigated 11 metabolic plasma biomarkers, with the hypothe

Purpose: The purpose of this study is to explore warehouse configuration in omni-channel retailing. Design/methodology/approach: A multiple case study is conducted with six large omni-channel retailers from three different sectors. Findings: The study shows an increase in the number, variation and frequency of flows passing through omni-channel warehouses. Along with an increased variety of stock

We implement the Grain-128AEAD stream cipher in hardware, using a 65 nm library. By exploring different optimization techniques, both at RTL level but also during synthesis, we first target high throughput, then low power. We reach over 33 GB/s targeting a high-speed design, at expense of power and area. We also show that, when targeting low power, the design only requires 0.23 $${\upmu }$$W runni

Background: There is an increasing interest in shorter, proximally loading, uncemented femoral stems. The aim of this study was to evaluate a new short stem type, its design based on a well-proven precursor, but with several new design features to facilitate easier insertion and possible preservation of proximal bone stock. It is available with or without a collar. Methods: The study includes 50 p

Given the limitations of the criminal justice system to address cases of sexual violence, feminist scholars are increasingly exploring alternative approaches to justice. Here I ask: What is the role of space in the way victim-survivors of sexual violence can experience justice outside the criminal justice system? Can an understanding of space help us develop justice responses to sexual violence? I

Background and Aims: Patients undergoing surgery are prone to infections, either at the site of surgery (superficial or organ-space) or at remote sites (e.g. pneumonia or urinary tract). Surgical site infections are associated with substantial morbidity and mortality, increased length of hospital stay and represent a huge burden to the health economy across all healthcare systems. Here we discuss

All you need to know about @LiesLahousse, first ECM to be granted the Early Career Member Award; #LSC2020; the newly elected assembly representatives for @EarlyCareerERS; and new @EuroRespSoc fellowship opportunities http://bit.ly/2OTgQlo

The nature of today’s business demands that Business Analytics (BA) extends to an operational level to better support employees in their decision-making. This is noticeable from the constant requests for new reports and changes in old ones at different employee levels. As a result, BA specialists or other power-users in functional departments are “bombarded” by these requests, and it becomes more

In the mid-2000s, Danish and Norwegian criminal procedural law underwent legislative amendments to strengthen the rights of complainants in cases of sexual violence and other cases of serious violations. While in Norway complainants were afforded participatory rights and stronger legal representation in court, this was largely not the case in Denmark. The aim of this chapter is to identify how the

The sayings of the Desert Fathers had an important role in the monastic education and were very widespread. Originally written down in Greek, they were soon translated into all the main languages in the medieval Europe, and underwent transformations as they were copied. The sayings were organized in different ways, mainly alphabetically or according to themes, and as they were copied the repertoir

In his history of Swedish poets who wrote in (Humanist) Greek (1785–9), Matthias Floderus claimed that before his time such a mania for versification raged in the Swedish universities in Uppsala, Turku, Tartu, and Lund that hardly one academic specimen appeared without it being embellished with Greek verses by students – also prose texts occur. That claim is only slightly exaggerated. This paper p

Enzymes of the xanthine oxidase family are among the best characterized mononuclear molybdenum enzymes. Open questions about their mechanism of transfer of an oxygen atom to the substrate remain. The enzymes share a molybdenum cofactor (Moco) with the metal ion binding a molybdopterin (MPT) molecule via its dithiolene function and terminal sulfur and oxygen groups. For xanthine dehydrogenase (XDH)

The xanthine oxidase (XO) family comprises molybdenum-dependent enzymes that usually form homodimers (or dimers of heterodimers/trimers) organized in three domains that harbor two [2Fe-2S] clusters, one FAD, and a Mo cofactor. In this work, we crystallized an unusual member of the family, the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli. This is the first example of an E. coli