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Objective: To develop evidence-based recommendations for the management of systemic glucocorticoid ( GC) therapy in rheumatic diseases. Methods: The multidisciplinary guideline development group from 11 European countries, Canada and the USA consisted of 15 rheumatologists, 1 internist, 1 rheumatologist-epidemiologist, 1 health professional, 1 patient and 1 research fellow. The Delphi method was u

The aim of this study was to investigate whether there is an association between overexpression of cyclin D1 and response to therapy. Immunohistochemical overexpression of cyclin D1 was determined in paraffin-embedded specimens from diagnostic biopsies of 89 primary cases of squamous cell carcinoma of the head and neck (SCCHN), using a polyclonal antiserum. The tumor response rates were estimated

Small-scale power plants based on the SOFC-GT (Solid Oxide Fuel Cell-Gas Turbine) system are foreseen for future application such as APU units in flight transportation systems or stationary power production. Although these new systems offer high load flexibility and potentially high efficiency, there are several constraints referring to thermal/mechanical stress of the fuel cell as well as to a po

The inverse scattering problem on branching graphs is studied. The definition of the Schrodinger operator on such graphs is discussed. The operator is defined with real potentials with finite first momentum and using special boundary conditions connecting values of the functions at the vertices. It is shown that in general the scattering matrix does not determine the topology of the graph, the pot

We investigated the relationship between trophic status and polychlorinated biphenyl (PCB) distribution in 19 Swedish lakes. We analyzed PCB in water, phytoplankton, zooplankton, fish and sediment during two sampling periods, in spring and summer. The mass of Sigma PCB in the lake sediments was positively related to lake trophy, i.e. more PCBs were accumulated and buried in the sediment of eutroph

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A large proportion of the adult population complains over difficulties in falling asleep, difficulties in maintaining sleep, or early awakening. Despite the fact that sleep disorders may be secondary symptoms to established or subclinical disease processes, more and more evidence has now accumulated to support the notion that sleep disorders may also play a primary role in the pathophysiology of c

In this paper we analyze the effects of body shadowing in multiple-input-multiple-output (MIMO) channels used for personal area networks (PANs). We give physical reasoning to why PANs may experience two different types of shadowing, and to support our argument, we present results from a measurement campaign for three different PAN channels with human influence. The campaign is performed using diff

This work introduces a novel analytical method for the detection and study of GAD65 autoantibodies, which have been implicated in the onset of type 1 diabetes. There is a clinical need for a rapid and automated assay for GAD65 autoantibodies. Therefore, this method was designed to exploit the advantages of bead injection (BI) analysis for enzyme-linked immunosorbent assays (ELISA). BI ELISA is a m

Neutron deficient nuclei near Sn-100 have been produced by fragmentation of a 1 (.) A GeV Sn-112 beam. The fragments were separated, identified and stopped in a highly segmented silicon strip detector stack. This detector measured the total energy of emitted beta(+)-particles. gamma-radiation was measured with surrounding detectors. The half-lives for many nuclides have been determined for the fir

Antibacterial activity of 17 strains of lactobacilli was tested against 10 strains of H. pylori. The inhibition observed was related to the acid production and the low pH attained. No relationship between CagA phenotype of H, pylori strains and tolerance to lactic acid was observed. In mixed cultures, L. acidophilus CRL 639 showed an autolytic behavior after 24 h of culture. At this moment, H. py[

In the 1940s, Swedish poetry saw the breakthrough of modernism. With the modernist style came a new kind of poetic aspiration towards the condition of music: semantic imitations of musical genres and attempts to create, with the help of the words' associations, an aesthetic effect similar to a musical effect. This type of intermediality, which I call semantic musicality, was inherited as a norm of

Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with (201)Tl. METHODS:

Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone. Based on results obtained from in vitro experiments, the protein was shown to bind osteoblasts via the integrin receptor alpha(v)beta(3). Due to OSAD's capacity to bind hydroxyapatite crystals, a role for the protein in the mineralization process has also been suggested. To test these hypotheses in an

In this letter, we demonstrate the realization of novel diodes, triodes, and logic gates with three-terminal ballistic junctions (TBJs) made from a semiconductor heterostructure. The approach exploits the ballistic nature of electron transport, which has emerged in the nanostructures. Importantly, we show that TBJs function as logic AND gates and can be used to construct other compound logic gates

A flow injection analysis (FIA) system for specific determination of L-glutamate in food samples based on a bi-enzymatic amplification system has been developed. The content of L-glutamate in the sample was amplified by cycling between L-glutamate dehydrogenase (GIDH) and a novel enzyme, D-phenylglycine aminotransferase (D-PhgAT). In this system, GIDH converts L-glutamate to 2-oxoglutarate with co