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Establishing functional assays for evaluation of synonymous variants associated with hereditary breast cancer

Breast cancer is the most commonly diagnosed cancer among women worldwide and a leading cause of cancer-related deaths. While most cancer cases are sporadic, approximately 5-10% are hereditary, with early-onset cases being more frequently associated with hereditary factors. They are often linked to mutations in DNA damage repair genes such as BRCA1/2, and their interacting partners, BARD1, BRIP1,

λ phage Induction Under Infection-Associated Stressors in Escherichia coli: Implications for Antimicrobial Resistance

Lysogenic phages, also known as temperate phages, play a crucial role in horizontal gene transfer and the dissemination of antimicrobial resistance (AMR). Upon induction, they may package bacterial DNA alongside or instead of their own, facilitating the spread of antibiotic-resistant genes. Phage induction can be triggered by the host bacterium's stress responses. While stress-induced prophage

Characterising Microglial Immunoreactivity In The Mouse Brain Post-Stroke: Impacts Of Environmental Enrichment

Stroke remains a leading cause of long-term disability worldwide, making effective recovery critical for minimizing residual impairments. Given the limited scope of pharmacological interventions in the post-stroke recovery phase, effective non-pharmacological strategies are essential for supporting better prognosis. One experimental approach to enhancing recovery in rodent models is environmental

Evaluating the Impact of Status Changes in Higher Education Institutions on Swedish Regional Innovation

As the drive to find sustainable and technological solutions to ongoing global problems becomes increasingly urgent, implementing timely innovation is needed now more than ever. The concept of regional innovation systems has recently gained popularity as a recipe for innovation and increasing knowledge transfer on a smaller scale. Specifically, the role of education in regional innovation systems

From Conquest to Capital: Slavery Persistence and Perception across History

This thesis investigates the historical development and contemporary persistence of slavery through a qualitative, comparative analysis of Roman, US, and modern forced labour systems. It addresses how the institutionalization and perception of slavery and the enslaved individual change over time and proposes race as the key difference between early modern and ancient forms of slavery. The rese

Equity and Innovation: Rethinking Technological Progress Through the lens of Inequality and Institutions

This paper investigates the role of inequality in shaping both the level and direction of innovation across 50 countries from 2015 to 2018. Drawing on the framework of national innovation systems and employing Principal Component Analysis (PCA) alongside multivariate OLS regressions, we construct composite indicators for governance, inequality, and institutional capacity. Our findings suggest that

Det kortaste spåret

In this essay I aim to find out about the closure of the Malmö-Simrishamns Järnväg, which was the shortest way from the eastern to the western coast of Skåne. By giving a historical background to the foundation and development of the railway and its importance for Skåne’s economic development, and through a qualitative investigation of studies made in this area of history of economics, I will try

Currency Flexibility vs. Monetary Union: A Comparative Study of Sweden and Finland’s Export Performance During the 2008 Financial Crisis

This thesis compares how Sweden and Finland’s contrasting exchange rate regimes shaped their export sector performance during the 2008 Global Financial Crisis. While both are small, open Nordic economies, Sweden maintained a floating currency and independent monetary policy, whereas Finland adopted the euro and ceded monetary control to the European Central Bank. The study evaluates export revenue

Consumer Influence on the Circular Economy: How understanding consumer behavior can help “close the loop” in the fashion textile industry

The transition towards a circular economy is an imperative function in the pursuit towards a more sustainable fashion textile industry. Through this transition, consumer cooperation and engagement are necessary points in guiding society towards more responsible shopping behaviors. This study extends the understanding of consumer behavior as it pertains to the purchasing, use, and disposal habits o

Donors in Transition: Comparing Aid Allocation Patterns in the Era of the Belt and Road Initiative

This paper analyzes Chinese aid allocation from 2013 to 2021 and compares it to traditional as well as emerging donors. In 2013, China launched the Belt and Road Initiative (BRI) which is considered one of China’s most ambitious development initiatives in the 21st century. To explore how the BRI reshaped China’s motives for aid allocation, I employ a two-part model to explain not only which countr

The Impact of Urban Green Spaces on Housing Prices in New York City

This study examines the impact of newly built parks on housing prices in New York City between 2011 and 2023. The case of New York City is especially interesting due to its high amount of new urban greening projects during the last few decades. Related to the different benefits of urban greening, there is evidence that parks increase the desirability of a neighborhood and thereby raise property va

Facing climate reality for waterfront areas

Throughout history, human civilisation and wildlife have instinctively settled close to water and coastlines out of necessity for resources. It has always been a natural instinct, yet we have also continually adapted to weather conditions and relocated when resources were found elsewhere. We have always been flexible and mobile, adapting to nature and allowing it to lead and guide us. With the ris

ECHOES OF STEEL AND SEA: Sustainable Regeneration of the Former Shipyard in Tianjin, China

Global post-industrial cities face the dual challenge of sustaining growth while repairing damaged ecosystems. Industrialization has left profound scars on both ecological networks and the urban fabric, demanding systematic spatial regeneration and environmental repair. Among these, abandoned brownfields hold unique potential: they offer opportunities to reshape urban structures, restore ecologica

Unimodal and Cross-Modal Iconicity in Japanese Ideophones: A cognitive-semiotic approach

Drawing on concepts from cognitive semiotics and phenomenology, this thesis investigates how Japanese ideophones are perceived by non-speakers of Japanese, aiming to clarify key concepts such as iconicity, cross-modality/unimodality and the ultimately the nature of language as a semiotic system. Three research questions guided the study: (1) What is the relation between primary and secondary iconi

Flexibly linked and isomeric piperidinium-based anion exchange membrane with enhanced alkaline stability for durable alkaline water electrolysis

A critical challenge in developing anion exchange membrane (AEM) water electrolysis is to design high-performance AEMs with chemical and mechanical stability under harsh alkaline environments. Herein, we report the rational design and synthesis of QP(T-3-Pip) featuring flexibly linked isomeric piperidinium cations via a Friedel-Crafts polyhydroxyalkylation between terphenyl and commercial 3-piperi

Perceptual structure of opposites across sensory modalities

Situated at the junction of Cognitive Semantics and Experimental Phenomenology, this study investigates how participants perceive the structure of 18 perceptual dimensions of opposites across the visual, auditory, tactile, gustatory and olfactory sensory modalities. The structures include three components: two poles (HIGH; LOW) and an intermediate (NEITHER HIGH NOR LOW). Participants were asked to