Establishing functional assays for evaluation of synonymous variants associated with hereditary breast cancer
Breast cancer is the most commonly diagnosed cancer among women worldwide and a leading cause of cancer-related deaths. While most cancer cases are sporadic, approximately 5-10% are hereditary, with early-onset cases being more frequently associated with hereditary factors. They are often linked to mutations in DNA damage repair genes such as BRCA1/2, and their interacting partners, BARD1, BRIP1,
