BACKGROUND: Dysregulation of the CCR3/CCL11 pathway has been implicated in the pathogenesis of choroidal neovascularisation, a common feature of late age-related macular degeneration (AMD). The aim of this study was to investigate the expression of CCR3 and its ligand CCL11 in peripheral blood in patients with neovascular AMD.METHODS: Patients with neovascular AMD and healthy controls were include

PURPOSE: To investigate the expression of the complement regulatory proteins CD46, CD55, and CD59 on peripheral leukocytes in neovascular age-related macular degeneration (AMD).DESIGN: Prospective, case-control study.METHODS: Thirty-five unrelated patients with neovascular AMD and 30 control individuals were included in this case-control study. All participants were subjected to a structured inter

PURPOSE: Association of neovascular age-related macular degeneration (AMD) with C-reactive protein (CRP) was previously reported, indicating a relation to systemic low-grade inflammation. However, visual impairment limits physical activity, and physical activity modulates CRP levels. Here, we investigated the impact of physical activity on CRP levels in patients with neovascular AMD and control in

OBJECTIVE: Dysregulation of retinal microglial activity has been implicated in the pathogenesis of neovascular age-related macular degeneration. Microglia activity can be regulated through the membrane protein CD200 and its corresponding receptor, the CD200 receptor (CD200R). Because both the ligand and the receptor are expressed on a broad spectrum of cell types, we set out to study the expressio

PURPOSE: To examine the association between age-related changes in the T-cell compartment and prevalence of age-related macular degeneration (AMD).DESIGN: Case-control study.PARTICIPANTS: A total of 117 AMD cases and 106 controls were included prospectively.METHODS: Fresh-drawn peripheral blood samples were processed for flow cytometric analysis of T-cell populations. Plasma samples were analyzed

PURPOSE: To investigate corneal endothelial cell density and morphology in type II diabetic and non-diabetic patients and to relate potential differences to the glycaemic status.METHODS: A prospective clinical study including 107 patients with type II diabetes and 128 non-diabetic patients. Sample size was based on a power calculation (power = 0.90; p = 0.05). The diabetic patients had on average

Cognitive linguistic and semiotic accounts of metaphor have addressed similar issues such as universality, conventionality, context-sensitivity, cross-cultural variation, creativity, and “multimodality.” However, cognitive linguistics and semiotics have been poor bedfellows and interactions between them have often resulted in cross-talk. This paper, which focuses on metaphors in Greek street art,

Determining the drivers of diversity is a major topic in biology. Due to its high level of micro-endemism in many taxa, Madagascar has been described as one of Earth's biodiversity hotspot. The exceptional Malagasy biodiversity has been shown to be the result of various eco-evolutionary mechanisms that have taken place on this large island since its isolation from other landmasses. Extensive phylo

There is a scarcity of instruments for assessing opportunities for residentswith psychiatric disabilities to engage in meaningful home-based activities.We thus developed the Perceived Meaning of Activity in Housing (PMA-H),containing four subscales (activity opportunities, social interaction, developingas a person, and organization and planning). The aim of the study was to investigate the content

This study investigates the impact of beach sediment supply on dune volume evolution through data analysis and model simulations of the Kennemer dunes in the Netherlands. A cross-shore sediment transport model (the CS-model) is applied with local time-averaged longshore sediment transport gradients derived from bathymetric and topographic observations. The model is used to study the relative impor

A new palaeoecological and palaeoclimatic project in the subalpine Abisko area, N Scandes, founded upon the pollen zone system defined by Sonesson is described. This model of vegetation history has been confirmed, although the chronology is partly revised. Sonesson's pollen diagrams are combined with new results from a lake sediment sequence at the tree-limit, which include sedimentologic, mineral

The remit of the INTIMATE project of the INQUA Palaeoclimate Commission is to synthesise marine, terrestrial and ice-core data for the North Atlantic region during the Last Glacial-Interglacial Transition (LGIT: ca 13-1014C kyr BP; ca 15-11.5 ice-core kyr BP). A major problem, however, is the difficulty of effecting correlations at a temporal resolution that are adequate for defining 'leads' and '

This study investigates grain-size sorting through longshore transport processes and how it influences dune evolution.The analysis is based on a data set of 58 sediment samples distributed alongshore over a 6.5-km-long sandy beach in Ängelholm, Sweden. Grain size differs significantly from north to south, where median grain size varies from about 0.4–0.15 mm. The long-term coastal evolution is der

The Journal of Water Management and Research (Vatten) celebrates 2019 its 75th anniversary with a special issue, republishing one article per decade from 1940 to 2010. In the present article, we summarize the development of Swedish water research and management based upon the material published in the journal. We read all issues of the journal, noting important trends, percentage of female authors

Background: Warfarin-treated patients with a prolonged Prothrombin Time (PT) can have a normal rotational thromboelastometry (ROTEM) clotting time (CT). A previous in vitro study found that activated prothrombin complex concentrates (APCC) could reverse an albumin-induced coagulopathy monitored with ROTEM, but that prothrombin complex concentrates (PCC) could not. The aim of this study was to inveBackground: Warfarin-treated patients with a prolonged Prothrombin Time (PT) can have a normal rotational thromboelastometry (ROTEM) clotting time (CT). A previous in vitro study found that activated prothrombin complex concentrates (APCC) could reverse an albumin-induced coagulopathy monitored with ROTEM, but that prothrombin complex concentrates (PCC) could not. The aim of this study was to inve