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Background: Low-molecular-weight heparin (LMWH) is recommended for thromboprophylaxis in adult intensive care unit (ICU) patients. Despite its widespread use, there is insufficient evidence on the optimal dose, and there appears to be practice variation. Determining the LMWH dosing strategy that most effectively balances the risks of venous thromboembolism (VTE) and bleeding may improve outcomes i

Introduction: Preclinical studies have demonstrated the ability of FLASH irradiation to expand the therapeutic window by sparing normal tissues. The heart is a critical organ at risk in patients receiving radiotherapy for thoracic cancers. This study aimed to quantify the cardiac sparing effects of photon FLASH delivered as single (FLASH) or FLASH split dose (FSD) exposures. Methods: Female C57BL/

The use of remote sensing and reanalysis weather data has not been adequately acknowledged for large-scale built environment applications, primarily regarding engineering analyses that traditionally rely on computationally expensive numerical models. This study employs a parsimonious data-driven approach concerning service life assessment of rain-exposed wooden components, enabling mapping and ass

Introduction: Individuals with Panic Disorder with or without Agoraphobia (PD/A) suffer from high rates of comorbidity. The present study aimed to address a knowledge gap about whether psychiatric comorbidity at baseline differentially influences, or moderates, outcomes in PD/A focused treatments.Methods: Data were drawn from a doubly-randomized preference trial of Panic Control Therapy (PCT) and

Intro: Population-based studies predominantly focused on carcinoma of the parotid gland (CPG) are rare. The study aims were to analyze the incidence of CPG and to assess treatment outcomes in relation to histopathology, preoperative diagnosis and adjuvant radiotherapy. Methods: A retrospective analysis was conducted on data from the Swedish Head and Neck Cancer Register (SweHNCR), including 1,018

Shared e-scooters (SEs) are increasingly integrated into urban mobility systems, yet their role in commuting and contribution to sustainable transport remain insufficiently understood. This study examines SE commuting patterns in Malmo, Sweden, focusing on their use as both a first-/last-mile connection to public transport and a primary commuting mode. Using pre-pandemic trip data from a major SE

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic stroma, which plays a crucial role in tumor biology and treatment resistance. While the stromal compartment is a defining histopathological feature of PDAC, its prognostic significance remains incompletely understood. This study aimed to quantify the stromal content in PDAC using digital pathology and

The bladder trigone is a distinct anatomical and functional subregion of the urinary bladder, defined by its triangular configuration between the ureteral orifices and the internal urethral orifice. Although traditionally less studied compared to the bladder dome and detrusor body, recent morphological, molecular, and transcriptomic analyses reveal that the trigone is highly specialized. Understan

Background Prothrombin is a vitamin K-dependent glycoprotein synthesized in the liver and circulating in blood as an inactive zymogen. The corresponding activated thrombin enzyme is a central player in hemostasis and thrombosis. Still, little is known about the individual variation over time of the prothrombin concentration in plasma in the general population. Objectives This study aimed to establ

Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by t

Hydrodeoxygenation (HDO) is a catalytic process applied for the reduction of oxygen levels in hydrocarbons from bio-derived feedstock as part of the processing into renewable fuel. The MoS2-based hydrotreating catalysts, currently being applied for the HDO reaction, are exposed to a complex environment consisting of O-rich hydrocarbons and water, which adversely impacts the state and stability of

Leigh syndrome is a fatal pediatric neurodegenerative disease caused by mitochondrial dysfunction, which can be modeled in the Ndufs4 KO mouse with mitochondrial respiratory chain complex I (CI) deficiency. This study explores NV354, a prodrug of succinate with enhanced oral bioavailability and brain uptake, as a potential therapy to counteract this devastating condition. NV354 modulated whole-bod

The chapter examines the flourishing hagiographical production during the Macedonian age, a period marked by intense rewriting of earlier Greek hagiography. This rewriting culminated in the Metaphrastic menologion, compiled by Symeon Metaphrastes in the late tenth century. Following the end of the iconoclastic controversy until Symeon, a clear progression is attested from an initial monastic inter

Introduction: Chronic pain is among the most common side effects of cancer in cancer patients and survivors, often co-occurring with fatigue, emotional distress and elevated fears of cancer recurrence. Both pain and the associated difficulties are associated with poorer outcomes. Longitudinal studies are needed that identify psychosocial factors that mitigate the effects of chronic cancer-related

This study presents a comprehensive investigation of the structural, microstructural, electrical, magnetic, and magnetoelectric properties of low-level substitution of Co3 + for Fe3+ ions in the perovskite B-site of BiFeO3 (BiFe1−xCoxO3, x = 0.01, 0.015 and 0.02). X-ray diffraction combined with Rietveld refinement confirms the retention of the rhombohedral R3c structure across all compositions, w