The cultivation of ethnographic discovery is not only about being insightful in the field by paying attention to unexpected events and unforeseen social processes. We should also search for potentially surprising or disturbing findings after the fieldwork. This can provide additional ways to create an original and sustainable understanding of research material. In this chapter, we discuss a study

Lignin is one of the world's most abundant organic polymers, and 2-pyrone-4,6-dicarboxylate lactonase (LigI) catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) in the degradation of lignin. The pH has profound effects on enzyme catalysis and therefore we studied this in the context of LigI. We found that changes of the pH mostly affects surface residues, while the residues at the active

A promise of genomics in precision medicine is to provide individualized genetic risk predictions. Polygenic risk scores (PRS), computed by aggregating effects from many genomic variants, have been developed as a useful tool in complex disease research. However, the application of PRS as a tool for predicting an individual's disease susceptibility in a clinical setting is challenging because PRS t

Background: Infertility is a well-known sequela of cancer treatment. Despite guidelines recommending early discussions about risk of fertility impairment and fertility preservation options, not all patients of reproductive age receive such information. Aims: This study aimed to investigate young adult cancer patients’ receipt of fertility-related information and use of fertility preservation, and

In order to tap the energy saving and climate mitigation potential of buildings, transaction costs of implementing energy efficient technologies need to be better understood and ultimately reduced. The objective of this paper is to identify and analyze the nature and scale of transaction costs resulting from the application of the passive house concept in energy efficient renovations. Related conc

Diabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial, mesangial and proximal tubular cells) in insulin sensitive and resistant conditions, and perform simultaneous transcriptomics and proteomics for integrated a

Antimicrobial peptides (AMPs), particularly host defense peptides (HDPs), have gained recognition for their role in host defense mechanisms, but they have also shown potential as a promising anticancer, antiviral, antiparasitic, antifungal and immunomodulatory agent. Research studies in recent years have shown HDPs play a crucial role in endothelial cell function and biology. The function of endot

Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation process that involves changes in the protein and lipid composition of the granules. Here, we show that insulin secretory granules form physical contacts with the endoplasmic reticulum and that the lipid exchange protein oxysterol-binding protein (OSBP) is recruited to these sites in a Ca2+-dependent manner.

Exercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkin

The industrial cities of the twentieth century were intimately dependent on and characterized by migration. This chapter focuses on describing and analyzing migration flows and migrant characteristics in relation to the general economic development of the industrial city of Landskrona. During the first decades of the century, migration tended to be circular between the city and the countryside. Mi

Considerable economic as well as environmental benefits can be achieved when appropriate industrial waste management is implemented. The objective of this study was to find a method of organizing a waste management system and of obtaining an overview of the whole system. The method proposed emphasizes the optimization of waste management with regard to energy, economy and environmental impact in s

Transcription of the third episode of the first season Nic:  Welcome, this is season one episode three of the Meridian, a podcast exploring the ins and outs of what's happening here at Lund Observatory.  This episode is airing on the 8th of October 2021, but if there are any listeners out there discovering the Meridian at a later date, then we just want to welcome you and hope that you find our ba

https://www.astro.lu.se/meridian-s01e03 - 2025-07-21

This page lists pasts talks at the CBBP seminars (2002 to 2023). The Computation Biology and Biological Physics group is now part of COSHE. See the calendar for future and recent COSHE seminars.2023Nov 08: Andreas Nilsson and Jesper Sjolte, GeologySynchronising and synthesising paleo data with chronologic uncertaintiesOct 30: Dmytro Perepolkin, CECIntroduction to Bayesian Parametric Quantile Regre

https://www.cec.lu.se/research/research-themes/computational-science-health-and-environment/past-cbbp-seminars - 2025-07-21