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Malignant hyperthermia susceptibility is diagnosed using an in vitro contracture test (IVCT). In families in which the mutation is known, genetic tests are also available. The inheritance pattern is regarded as autosomal dominant, which predicts equal proportions of men and women affected. The aim of this study was to investigate whether there were sex differences in the diagnostic outcome of the

Future adaptation to changes in the environment depends on the existence of additive genetic variances within populations. Recently, considerable attention has also been given to the non-additive component, which plays an important role in inbreeding depression and bottleneck situations. In this study, I used data from a North Carolina II crossing experiment, analysed with restricted maximum-likel

Given difficult conditions in different regions of the world, it is no wonder that people embark on journeys to regions where they may feel secure, seek refuge, be able to acquire a livelihood, as well as carry on a type of living. At the same time, when migrants arrive in a new country that they have hitherto never been to, there is an expectation that they will integrate into the host country’s

Research on priority-setting for research, development, and innovation (RDI) often does not take into account the many challenges associated with translating priorities into RDI programs and projects. Such implementation challenges are typically handled by RDI program officers at funding agencies i.e. those officers that manage RDI programs and projects. To address this challenge, this paper utili

Relevant to, and drawing from, a range of disciplines, the chapters in this collection show the diversity, and applicability, of research in Bayesian argumentation. Together, they form a challenge to philosophers versed in both the use and criticism of Bayesian models who have largely overlooked their potential in argumentation. Selected from contributions to a multidisciplinary workshop on the to

The breaking with regime logics is one of the key leverage points to enable a socio-technical transition. Understanding how, and under what conditions, this may happen is thus an important task for transition studies. Recent research on socio-technical regimes has shown that they may be less geographically bound than previously assumed. Regimes may instead be replicated and reinforced globally thr

The exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some currenThe exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some curren

Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes

BACKGROUND: Patients diagnosed with Crohn disease (CD) are known to be at an increased risk of bowel cancers and lymphoma. CD is an autoimmune disease and we hypothesize that the patients are predisposed to a wider spectrum of cancers.PATIENTS AND METHODS: A CD research database was constructed by identifying hospitalized CD patients from the Hospital Discharge Register and cancer patients from th

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual components of the insulin resistance (metabolic

Research has shown that positive evaluations of home are important for very old people’s health, well-being and independence in daily life. The rationale for the present study derives from our survey study findings, confirming such associations also in a younger cohort (N = 371). The purpose of this study was to further increase the understanding of the dynamics of meaning of home and health among

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples. The two major subgroups of C3 glomerulopathy — dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) — have overlapping clinical and pathologica