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Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene varian

Autophagy has emerged as a cell survival mechanism critical for cellular homeostasis, which may play a protective role in atherosclerosis. ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease. However, it is unknown whether ATG16L1 is involved in atherosclerosis. Our aim was to analyze ATG16L1 expression in carotid atherosclerotic p

The following presentation is primarily intended to stimulate and facilitate a future development towards an improved situation for a reliability based structural fire engineering design of timber structures. The state of the art is reviewed and a structure of a design guide or a model code is outlined. The document is written in a partially operational manner, allowing practical application for s

“The Future is distributed: a vision of sustainable economies” is a collection of case studies on distributed economies, a concept describing sustainable alternatives to the existing business models. The authors of this publication are international Masters students of the Environmental Sciences, Policy and Management Programme at the International Institute for Industrial Environmental Economics

The situation for minorities in the Middle East in the midst of transformations are complicated. Not least after the so called Arab Uprisings. In this conference we focused on the situation for Christians in the Middle East. Scholars, journalists and activists from Iraq, Syria, Egypt, Libanon and Palestine/Israel met in Lund for discussions and seminar during December 5-7. The conference was co-or

Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigate associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to cla

Allvarliga tillbud och olyckor inom flygtrafiken är relativt ovanligt, men när de inträffar ställs höga krav på kabinpersonalens förmåga att uppträda auktoritativt och effektivt. Det är dock inte bara vid ett direkt olyckstillbud det ställs stora krav på kabinpersonalens förmåga att hantera kritiska situationer. Det finns en hel flora av incidenter som kräver professionell hantering, t ex när passAlthough serious accidents or near-accidents are relatively rare in airline traffic, when they occur cabin attendants are expected to act effectively and with authority. However, the ability of cabin attendants to intervene professionally is also called for in other critical situations, such as when incidents that are frightening for the passengers occur or when passengers suddenly become ill. The

The role of mammalian Transient Receptor Potential Ankyrin 1 (TRPA1) as a mechanosensor is controversial. Here, we report that purified human TRPA1 (hTRPA1) with and without its N-terminal ankyrin repeat domain responded with pressure-dependent single-channel current activity when reconstituted into artificial lipid bilayers. The hTRPA1 activity was abolished by the thiol reducing agent TCEP. Thus

Over the last two decades, electrification has gained importance as a means to decarbonise the transport sector. As the number of Electric Vehicles (EVs)increases, it is important to consider broader system aspects as well, especially when deciding the type, coverage, size and location of the charging infrastructure required. In this article, a Multi-Agent model depicting long distance transport i

This thesis, drawing from several empirical investigations, reaches the conclusion that there seems to be a positive correlation between the level of democracy and the level of state capacity in Latin American countries. This correlation is explained by a hypothesis derived from Rational Choice theory. With some important caveats, this conclusion is then applied to the discussion about democracy a

The incidence of acute appendicitis and the total number of appendectomies performed in the adult population admitted to our medical center are both decreasing. The cause is not clear. Better nutrition and the wide-spread use of antibiotics are two possible factors which come to mind, but we know of no scientific evidence that these are responsible. There has been a slight decrease in the mean die