Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases and is characterized by high chemoresistance, leading to the lack of effective therapeutic approaches and grim prognosis. Despite increasing understanding of the mechanisms of chemoresistance in cancer and the role of ATP-binding cassette (ABC) transporters in this resistance, the therapeutic potential of their pharmaco

Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease, lacking effective therapeutic approaches and leaving PDAC patients with a poor prognosis. The life expectancy of PDAC patients has not experienced a significant change in the last few decades with a five-year survival rate of only 8%. To address this unmet need, novel pharmacological targets must be identified for clinical inter

Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exerting its anti-inflammatory effect. We show that m

AbstractDead standing trees (DSTs) generally decompose slower than wood in contact with the forest floor. In many regions, DSTs are being created at an increasing rate due to accelerating tree mortality caused by climate change. Therefore, factors determining DST fall are crucial for predicting dead wood turnover time but remain poorly constrained. Here, we conduct a re-analysis of published DST f

Accurate monitoring of the spatiotemporal variations in the gross primary productivity (GPP) in coastal wetlands is essential for blue carbon quantification. However, the currently available moderate-spatial-resolution GPP algorithms and products may contain large uncertainties and may rarely meet the demands of tidal wetland research. In this paper, we examine two statistical methods, namely, sim

Several plasticizing chemicals induce endocrine disrupting effects in humans, and the indoor environment is suggested to be a source of exposure. As children are particularly vulnerable to the effects from exposure to endocrine disrupting chemicals (EDCs), it is essential to monitor exposure to EDCs such as phthalates and non-phthalate plasticizers in indoor environments intended for use by childr

Catch-up phenomena have been studied intensively in many manufacturing industries, but they have not been well explored in creative industries. Moreover, the internal heterogeneity of different segments within a specific industry has also largely been overlooked in the catch-up literature. This paper fills these gaps by analyzing the catch-up of a creative industry—the online game industry in Chin

This paper investigates realisations of elliptic differential operators of general order on manifolds with boundary following the approach of Bär-Ballmann to first order elliptic operators. The space of possible boundary values of elements in the maximal domain is described as a Hilbert space densely sandwiched between two mixed order Sobolev spaces. The description uses Calderón projectors which,

Inflammatory mediators induce emergency myelopoiesis and cycling of adult hematopoietic stem cells (HSCs) through incompletely understood mechanisms. To suppress the unwanted effects of inflammation and preserve its beneficial outcomes, the mechanisms by which inflammation affects hematopoiesis need to be fully elucidated. Rather than focusing on specific inflammatory stimuli, we here investigated

Buffer management for biopharmaceutical purification processes include buffer preparation, storage of buffers and restocking the buffers when needed. This is usually performed manually by the operators for small scale operations. However, buffer management can become a bottleneck when running integrated continuous purification processes for prolonged times, even at small scale. To address this iss

Three orthogonal techniques were used to provide new insights into thermally induced aggregation of the therapeutic protein Somatropin at pH 5.8 and 7.0. The techniques were Dynamic Light Scattering (DLS), Asymmetric Flow-Field Flow-Fractionation (AF4), and the TEM-based analysis system MiniTEM™. In addition, Differential Scanning Calorimetry (DSC) was used to study the thermal unfolding and stabi

Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure. Here, we integrate extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling. In cont

After the commercial emergence of 5G, the research community is already putting its focus on proposing innovative solutions to enable the upcoming 6G. One important lesson put forth by 5G research was that scaling up the conventional multiple-input-multiple-output (MIMO) technology by increasing the number of antennas could be extremely beneficial for effectively multiplexing data streams in the s

Vid Örebro universitet anordnades våren 2021 för andra gången konferensen Forskning om högre utbildning. Ett tema för konferensen var utveckling av högskolepedagogisk forskning. Högre utbildning publicerar nu tre texter på detta tema som en fördjupad diskussion. De kan läsas var för sig eller tillsammans. Den första utgörs av Sverre Wides inledningsanförande från konferensen. Efter inbjudan från rIn spring 2021, Örebro University arranged the second Swedish conference for Research in Higher Education. One of the themes for the conference was the development of higher education studies as a specific branch of this research. Our journal, Högre utbildning, now publishes three contributions linked to this theme as in-depths essays. These may be read separately or together. The first consists o

Intact forests and protected areas (PAs) are central to global biodiversity conservation and nature-based climate change mitigation. However, cropland encroachment threatens the ecological integrity and resilience of their functioning. Using satellite observations, we find that a large proportion of croplands in the remaining forests globally have been gained during 2003–2019, especially for high-

Sea urchins can detect light and move in relation to luminous stimuli despite lacking eyes. They presumably detect light through photoreceptor cells distributed on their body surface. However, there is currently no mechanistic explanation of how these animals can process light to detect visual stimuli and produce oriented movement. Here, we present a model of decentralized vision in echinoderms th