Ubiquitination of pro-IL-1β in response to GAS infection of macrophages
Ubiquitination is a post-translational modification process that has a very important role in the homeostasis of eukaryotic cells. Linkage-specific ubiquitination determines the final destination of modified protein. Ubiquitination has also been reported to regulate inflammasome function and IL-1β degradation. Secretion of IL-1β by macrophages in response to inflammasome activation is a key proces
