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Coarse-Graining of Ionic Microgels: Theory and Experiment

In this work, we discuss the statistical mechanics of many-body systems consisting of electrically charged microgels, and we show that their collective behavior is determined by an interplay between the screened electrostatic and the elastic contributions to their effective interaction potential. The former is derived by means of a statistical-mechanical approach due to Denton [A. R. Denton, Phys.

Secondhand Smoking in Swedish Municipal Home Nursing: A Qualitative Pilot Study

Objective The purpose of this study was to explore licensed practical nurses (LPNs) views of being exposed to secondhand smoke in municipal home nursing care. Design and sample Using a qualitative approach, data were collected through three focus group interviews with 15 LPNs, smokers, and nonsmokers. Qualitative content analysis was used to interpret the interview text. Results Exposure to second

Inclusion of a single-tail amino acid-based amphiphile in a lipoplex formulation: Effects on transfection efficiency and physicochemical properties

Effects of the addition of a cationic amino acid-based synthetic amphiphile, arginine N-lauroyl amide dihydrochloride (ALA), to a lipid-based transfection formulation have been investigated. It is shown that the inclusion of ALA results in a substantial enhancement of the transfection capability of lipoplexes prepared with liposomes of 1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine and chol

Fiber mediated receptor masking in non-infected bystander cells restricts adenovirus cell killing effect but promotes adenovirus host co-existence.

The basic concept of conditionally replicating adenoviruses (CRAD) as oncolytic agents is that progenies generated from each round of infection will disperse, infect and kill new cancer cells. However, CRAD has only inhibited, but not eradicated tumor growth in xenograft tumor therapy, and CRAD therapy has had only marginal clinical benefit to cancer patients. Here, we found that CRAD propagation

On the spectrum of the Cesàro operator on spaces of analytic functions

This paper concerns the Cesàro operator acting on various spaces of analytic functions on the unit disc. The remarkable fact that this operator is subnormal when acting on the Hardy space H2 has lead to extensive studies of its spectral picture on other spaces of this type. We present some of the methods that have been used to obtain information about the spectrum of the Cesàro operator acting on

Characterization of humoral responses to soluble trimeric HIV gp140 from a clade A Ugandan field isolate

Trimeric soluble forms of HIV gp140 envelope glycoproteins represent one of the closest molecular structures compared to native spikes present on intact virus particles. Trimeric soluble gp140 have been generated by several groups and such molecules have been shown to induce antibodies with neutralizing activity against homologous and heterologous viruses. In the present study, we generated a reco

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Abstract in German Für die Verbreitung in Ausser-Schartauschen Kreisen war es von Bedeutung, dass Roos von Anfang an nicht nur als der von Henric Schartau geförderte Verfasser von Andachtsbüchern bekannt wurde, sondern dass er schon vor Schartau als Autor von biblischen Einführungen und sogenannten Gesprächsbüchern bekannt war und respektiert wurde. Für die Wertschätzung seiner Meinung und seiner

Apyrase treatment of myocardial infarction according to a clinically applicable protocol fails to reduce myocardial injury in a porcine model

Background: Ectonucleotidase dependent adenosine generation has been implicated in preconditioning related cardioprotection against ischemia-reperfusion injury, and treatment with a soluble ectonucleotidase has been shown to reduce myocardial infarct size (IS) when applied prior to induction of ischemia. However, ectonucleotidase treatment according to a clinically applicable protocol, with admini

Hydrogen Production for Refuelling Applications

Since 2007, Intelligent Energy (IE) has been involved in developing technologies and services in the hydrogen generation space with E.ON Gas Sverige AB and Swedish Gas Centre. The aim of this work is to support the development of a high-profile demonstration of hydrogen generation technologies in a Swedish context. The overall objective of the demonstration is to deploy a reforming based hydrogen

Ultra-Wide-Band Propagation Channels

Understanding ultra-wide-band (UWB) propagation channels is a prerequisite for UWB system design as well as communication-theoretic and information-theoretic investigations. This paper surveys the fundamental properties of UWB channels, pointing out the differences to conventional channels. if the relative bandwidth is large, the propagation processes, and therefore path loss and shadowing, become

Evaluation of macroporous blood and plasma scaffolds for skeletal muscle tissue engineering

The field of tissue engineering has a growing need for suitable scaffold materials to become attractive as a clinical therapy. To use a completely autologous construct to repair a damaged or diseased tissue is an appealing thought. As a model system, two types of scaffolds were prepared from biological fluids: blood and plasma. The prepared scaffolds formed a macroporous structure with elastic mec

When is Thrombolysis for Acute Lower Limb Ischemia Worthwhile?

Objectives: To find variables associated with outcome following thrombolytic treatment for acute lower limb ischemia. Design: Re-analysis of a prospective multicentre study. Material and methods: One hundred and twenty-one patients with acute lower limb ischemia previously included in a randomised study comparing high- with low-dose thrombolysis were re-analysed ignoring the mode of lytic treatmen

Pay Differentials and Gender-Based Promotion Discrimination in a Dual Labour Market

Abstract Historical studies indicate that determinants of the gender wage gap have varied through history. This paper suggests that employment discrimination dominated over wage discrimination in clerical work in Sweden in the mid-1930s. Women were largely excluded from career paths in the offices. This is explained within an analytical framework, in which segmented labour market theory, notably c

The Measures of Criminal Attitudes and Associates (MCAA): Further testing of structural and criterion-related validity

The validity of a Swedish translation of the Measures of Criminal Attitudes and Associates (MCAA) was evaluated. All four subscales showed acceptable reliability, but the Entitlement scale can be improved by replacing items with low loadings. Confirmatory factor analysis supported a model with one common criminal attitude factor and three subfactors (corresponding to subscales of the test). The An

Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-I variants emerging during AIDS progression

Background: At early stages of infection CCR5 is the predominant HIV-1 coreceptor, but in approximately 50% of those infected CXCR4-using viruses emerge with disease progression. This coreceptor switch is correlated with an accelerated progression. However, those that maintain virus exclusively restricted to CCR5 (R5) also develop AIDS. We have previously reported that R5 variants in these "non-sw

Transcriptional Down-Regulation of Thromboxane A(2) Receptor Expression via Activation of MAPK ERK1/2, p38/NF-kappa B Pathways

Background: We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A(2) (TP) receptors was studied. Methods and Results: After organ culture of the arteries, VSMC TP receptors were studied by using myography, real-time PCR and immuno