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The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a

John-Paul Himka’s new book, Ukrainian Nationalists and the Holocaust: OUN and UPA’s Participation in the Destruction of Ukrainian Jewry, 1941-1944, represents a milestone in research on the complicity of the OUN-UPA in the Holocaust. Based on decades worth of research in dozens of archives around the world, Himka makes a well-documented and indisputable case for Ukrainian nationalist involvement i

Quantum control is implemented in a 2-beam fs/ns rotational CARS setup via a second control pulse with variable delay. The potential of the concept for improved diagnostics is demonstrated by species-selective enhancement/annihilation via field-free alignment.

Jet impingement cooling is an effective way for thermal management in electronics, prevailed over many other single heat transfer modes. In general, jet arrays are better than a single jet, enhancing jet cooling performance. However, the performance of jet arrays is strongly dependent on the jet configurations, e.g., adjacent jet interval and hole-to-surface distance. Thus, in this study, jet impi

INTRODUCTION Women and their families are often excluded from reproductive decisionmaking processes in postnatal care, and do not know which choices they have. Shared decision-making is a critical but challenging component of maternity care quality. The aim was to explore women's experience of the decision-making process about early return from hospital with home-based postnatal midwifery care. ME

John-Paul Himka’s new book, Ukrainian Nationalists and the Holocaust: OUN and UPA’s Participation in the Destruction of Ukrainian Jewry, 1941-1944, represents a milestone in research on the complicity of the OUN-UPA in the Holocaust. Based on decades worth of research in dozens of archives around the world, Himka makes a well-documented and indisputable case for Ukrainian nationalist involvement i

Påve Benedikt betraktas allmänt som en skarp intellektuell tänkare och som en av vår tids främsta katolska teologer. Det är som teologen på Petri stol han går till historien. I artikeln ges en översikt över hans verksamhet som teolog och kyrkoman.

We summarize what we assess as the past year's most important findings within climate change research: limits to adaptation, vulnerability hotspots, new threats coming from the climate-health nexus, climate (im)mobility and security, sustainable practices for land use and finance, losses and damages, inclusive societal climate decisions, and ways to overcome structural barriers to accelerate mitig

This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich-club) brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex on their relevance. We analyzed MRI data recorded at index stroke and ~3-months modified Rankin Scale (mRS) data from patients with acute ischemic stroke enrolle

Background: Tissue factor is the main initiator of blood coagulation, and tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the initiation of blood coagulation. The genetic variation of TFPI and the relation to venous thromboembolism (VTE), that is, venous thrombosis and pulmonary embolism, remains to be clarified. This exome sequencing study aimed to determine the molecular epide

Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently two concordant documents have been published: the 6th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen, and the Internationa

RATIONALE: Idiopathic pulmonary fibrosis is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to non-genetic factors, have been consistently associated with IPF. Rare variants identified by candidate gene, family-based, and exome studies have also been reported to associate with IPF. However, the extent to which rare variants genome-wide may contribut

This review presents how the boreal and the tropical forests affect the atmosphere, its chemical composition, its function, and further how that affects the climate and, in return, the ecosystems through feedback processes. Observations from key tower sites standing out due to their long-term comprehensive observations: The Amazon Tall Tower Observatory in Central Amazonia, the Zotino Tall Tower O

Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric post

Det är sorgligt att Tro och solidaritet sänker sig till denna låga debattnivå av personangrepp istället för att framföra sakligt grundad kritik som skulle kunna föra debatten framåt. Ardins personligt upprörda tonfall blir för mig ytterligare ett bevis på att det är något som skaver och att det finns lik i garderoben. Jag upp­repar mitt förslag om en oberoende utredning av relationen mellan Tro oc

PurposeGermline genetic testing for BRCA1 and BRCA2 variants has been a part of clinical practice for >2 decades. However, no studies have compared the cancer risks associated with missense pathogenic variants (PVs) with those associated with protein truncating (PTC) variants.MethodsWe collected 582 informative pedigrees segregating 1 of 28 missense PVs in BRCA1 and 153 pedigrees segregating 1 of