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OBJECTIVE To characterize distinct islet autoantibody profiles preceding stage 3 type 1 diabetes RESEARCH DESIGN AND METHODS The T1DI (Type 1 Diabetes Intelligence) study combined data from 1,845 genetically susceptible prospectively observed children who were positive for at least one islet au-toantibody: insulin autoantibody (IAA), GAD antibody (GADA), or islet antigen 2 antibody (IA-2A). Using
Background: Colon capsule endoscopy (CCE) has gained momentum as an alternative modality for the investigation of the lower gastrointestinal tract. Of the few challenges that remain, the comparison and – eventually – matching of polyps at different timestamps leads to the potential for double reporting and can contribute to false-positive findings and inaccuracies. With the impending artificial in
Background: Induced hypothermia post-cardiac arrest is neuroprotective in animal experiments, but few high-quality studies have been performed in larger animals with human-like brains. The neuroprotective effect of postischemic hypothermia has recently been questioned in human trials. Our aim is to investigate whether hypothermia post-cardiac arrest confers a benefit compared to normothermia in la
Context: The intensification and expansion of human activities have caused profound changes in global wetlands and their associated aquatic bird communities. Understanding the mechanisms that drive the spatial assemblages of wetland birds is important for the development of effective conservation and management strategies. Objectives: The overall objective was to evaluate the influence of wetland
Laser-induced thermal grating spectroscopy (LITGS) has been proved for accurate thermometry and measurement of energy transfer processes in molecules. While electronic transitions are often used for excitation in previous LITGS works, here we report laser-induced thermal gratings formed by direct excitation of CO2 with an infrared (IR) laser at wavelength near 2 μm, with which high signal-to-noise
We demonstrate reliable machine-learned tuning of quantum-dot-based artificial Kitaev chains to Majorana sweet spots, using the covariance matrix adaptation algorithm. We show that a loss function based on local tunneling spectroscopy features of a chain with two additional sensor dots added at its ends provides a reliable metric to navigate parameter space and find points where crossed Andreev re
Straw and nutrients retained in soil are crucial for priming effect (PE) and consequently for soil organic matter (SOM) turnover. However, the mechanisms by which carbon (C), nitrogen (N), and phosphorus (P) and their stoichiometric ratios impact microbial communities and regulate the PE intensity remain controversial, particularly in the flooded rice soils. In this work, the PE dynamics and micro
The major driver of the climate and biodiversity crisis is our unsustainable production and consumption patterns, but the need to transition to a circular and resource- efficient economy has not been sufficiently addressed by policymakers. Policies supporting circular industrial transition are still rare, not the least in contrast with the recent momentum gained by green industrial policy in EU an
Abstract: The Abrasion–Ablation Monte Carlo for Colliders (AAMCC) model is used to study the characteristics of spectator matter in central collisions of relativistic 238U nuclei, which are sensitive to the mutual orientation and the degree of deformation of the colliding nuclei. It is shown that the multiplicity of spectator neutrons and their forward-backward asymmetry substantially depend on th
Despite the successes in the use of artificial intelligence systems for image analysis, in certain critical applications, the final decision-making should remain with the human operator. To facilitate the working conditions of an unmanned aerial vehicle (UAV) pilot during prolonged missions, an auxiliary narrow-angle video camera is installed on board the UAV. This camera can be positioned indepen
BACKGROUND: Health workers' (HWs') perspectives on the quality of maternal and newborn care (QMNC) are not routinely collected. In this cross-sectional study, we aimed to document HWs' perspectives on QMNC around childbirth in 12 World Health Organization (WHO) European countries.METHODS: HWs involved in maternal/neonatal care for at least one year between March 2020 and March 2023 answered an onl
The construction industry is ranked number one compared to other sectors when it comes to waste generated in the European Union. Reuse of products is a priority within the European Union to reduce the need for virgin materials and to reduce waste. Looking back at past practices, various approaches have been suggested to increase reuse of construction products, although these approaches have fallen
The widespread diffusion and adoption of digital methods and tools into archaeological practice have deeply affected and often transformed how archaeologists interact with material culture, impacting also on the collaborative and reflective aspects of excavation methods. Moreover, these transformations in archaeological methods and practice, have also brought about advancements in data collection,
ObjectivesLack of trust and transparency is stressed as a challenge for clinical implementation of Artificial Intelligence (AI). In breast cancer screening, AI-supported reading shows promising results but more research is needed on how medical experts, that are facing the integration of AI into their work, reason about trust and information needs. From a sociotechnical information practice perspe
It is assumed that nursing is performed on a scientific knowledge-based approach toward patients that considers the wellbeing of the whole person. The meaning and understanding are essentialwhen conceptualizing the idea of caring for the whole person and how this is applied by nurses inhealthcare. However, the meaning and understanding of holism varies widely according to research. The aim of this
It is generally recommended to refrain from taking rectal biopsies in radioproctopathy. Herein we describe the clinical characteristics of urorectal fistulas after such biopsies in five patients. Conservative treatment is rarely successful. Diagnostic difficulties and comorbidities limiting the possibilities for radical surgical treatment options (i e pelvic exenteration) for urorectal fistulas ar
Increasing recognition of germline DDX41 variants in patients with hematological malignancies prompted us to provide DDX41-specific recommendations for diagnosis, surveillance, and treatment. Causative germline variants in the DDX41 predispose to the development of myeloid neoplasms (MNs), especially myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Almost 3%–5% of all patients with
