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Metastatic sites and survival in lung cancer.

Population-based data on metastatic sites and survival in site-specific metastases are lacking for lung cancer and for any cancer because most cancer registries do not record metastases. This study uses a novel population-based approach to identify metastases from both death certificates and national inpatient data to describe metastatic pathways in lung cancer patients.

GDNF fails to exert neuroprotection in a rat {alpha}-synuclein model of Parkinson's disease.

The neuroprotective effect of the glial cell line-derived neurotrophic factor has been extensively studied in various toxic models of Parkinson's disease. However, it remains unclear whether this neurotrophic factor can protect against the toxicity induced by the aggregation-prone protein α-synuclein. Targeted overexpression of human wild-type α-synuclein in the nigrostriatal system, using adeno

Lucid Dreams, Perfect Nightmares: Consciousness, Capitalism and Our Sleeping Selves

Review article discussing three books: Thompson, Evan. Waking, Dreaming, Being: Self and Consciousness in Neuroscience, Meditation, and Philosophy. New York: Columbia University Press, 2014. Mavromatis, Andreas. Hypnagogia: The Unique State of Consciousness between Wakefulness and Sleep. London: Thyrsos Press, 2010. Crary, Jonathan. 24/7: Late Capitalism and the Ends of Sleep. London: Verso,

Complexes formed between DNA and poly(amido amine) dendrimers of different generations - modelling DNA wrapping and penetration.

This study deals with the build-up of biomaterials consisting of biopolymers, namely DNA, and soft particles, poly(amido amine) (PAMAM) dendrimers, and how to model their interactions. We adopted and applied an analytical model to provide further insight into the complexation between DNA (4331 bp) and positively charged PAMAM dendrimers of generations 1, 2, 4, 6 and 8, previously studied experimen

Money Matters: Teflonic Identity Manoeuvring in the Investment Banking Sector

In this paper we address identity issues in relation to senior employees in the UK investment banking sector. Drawing on in-depth material, the study demonstrates their marginal concerns about identity issues or engagement in what is typically viewed as identity work. Instead they had what we refer to as an identity minimalism orientation and met potential challenges to identity with what we conce

Active Inclusion as an Organisational challenge: integrated anti-poverty policies in three European countries :

Active inclusion aims at the reduction of poverty by strengthening the agency of excluded persons by the provision of a minimum income, activation and social services. The contribution to poverty alleviation is determined by expenditure levels and the organisation of these three policy fields. This can be shown by three examples: The comprehensive Swedish regime is characterised by high expenditur

Adsorption of beta-casein to hydrophilic silica surfaces. Effect of pH and electrolyte

Adsorption of beta-casein to hydrophilic silica surfaces has been studied as an effect of pH and electrolyte, in the latter concentration, valency, and specificity (calcium or magnesium) have been considered. The used protein concentration has been an order of magnitude below the critical aggregation concentration, which implies that the protein is in monomeric form. By varying the salt concentrat

Lessons Learned From Two Consecutive Cleft Lip and Palate Missions and the Impact of Patient Education.

Two consecutive cleft missions were conducted in Guwahati, northeastern India in December 2010 and January 2011. In the later mission, a standardized patient education program for postoperative care was introduced. The objective of this study was to retrospectively evaluate the impact of the patient education program on cleft lip complications in terms of wound infection and dehiscence. Two hundre

β-Microseminoprotein Endows Post Coital Seminal Plasma with Potent Candidacidal Activity by a Calcium- and pH-Dependent Mechanism.

The innate immune factors controlling Candida albicans are mostly unknown. Vulvovaginal candidiasis is common in women and affects approximately 70-75% of all women at least once. Despite the propensity of Candida to colonize the vagina, transmission of Candida albicans following sexual intercourse is very rare. This prompted us to investigate whether the post coital vaginal milieu contained facto

Formation of highly structured cubic micellar lipid nanoparticles of soy phosphatidylcholine and glycerol dioleate and their degradation by triacylglycerol lipase

Lipid nanoparticles of reversed internal phase structures, such as cubic micellar (I2) structure show good drug loading ability of peptides and proteins as well as some small molecules. Due to their controllable small size and inner morphology, such nanoparticles are suitable for drug delivery using several different administration routes, including intravenous, intramuscular and subcutaneous inje

Comparison of clinicians and an artificial neural network regarding accuracy and certainty in performance of visual field assessment for the diagnosis of glaucoma.

Purpose: To compare clinicians and a trained artificial neural network (ANN) regarding accuracy and certainty of assessment of visual fields for the diagnosis of glaucoma. Methods: Thirty physicians with different levels of knowledge and experience in glaucoma management assessed 30-2 SITA Standard visual field printouts that included full Statpac information from 99 patients with glaucomatous

Low-order feedforward controllers: Optimal performance and practical considerations

Feedforward control from measurable disturbances can significantly improve the performance in control loops. However, tuning rules for such controllers are scarce. In this paper design rules for how to choose optimal low-order feedforward controller parameter are presented. The parameters are chosen so that the integrated squared error, when the system is subject to a step disturbance, is minimize

Patterns and magnitude of Zn:Ca in otoliths support the recent phylogenetic typology of Salmoniformes and their sister groups

La chimie des otolithes de poissons sert a associer les poissons a des environnements specifiques. La chimie des otolithes peut aussi potentiellement servir d'outil dans la recherche phylogenetique, comme nous le demontrons ici chez les poissons salmonides et les taxons apparentes. Des cartes bidimensionnelles de la chimie de Zn:Ca dans les otolithes montrent des oscillations annuelles d'amplitude

Consumer Perceptions of Food Packaging: Contributing to or Counteracting Environmentally Sustainable Development?

Packaging has a fundamental role in ensuring safe delivery of goods throughout supply chains to the end consumer in good condition. It also has great potential to contribute to sustainable development. This paper explores and provides insights on Swedish consumer perceptions and knowledge of environmental aspects of food packaging and elaborates on how these can contribute to or counteract environ

Anticancer effects of baicalein on hepatocellular carcinoma cells.

The therapeutic potential of baicalein against hepatoma cells was evaluated in vitro and in vivo. In cell viability assays, baicalein showed significant cytotoxicity against the hepatocellular carcinoma cell lines H22, Bel-7404, and Hep G2 and moderate cytotoxicity against immortalized human hepatocytes. Baicalein induced G0/G1-phase arrest in hepatocellular carcinoma cells, inhibited AKT, and pro

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

The recognition of carbohydrates by proteins is a fundamental aspect of communication within and between living cells. Understanding the molecular basis of carbohydrate-protein interactions is a prerequisite for the rational design of synthetic ligands. Here we report the high- to ultrahigh-resolution crystal structures of the carbohydrate recognition domain of galectin-3 (Gal3C) in the ligand-fre

Impact of a fast-track surgery programme for pancreaticoduodenectomy.

Fast-track (FT) programmes are multimodal, evidence-based approaches to optimize patient outcome after surgery. The aim of this study was to evaluate the safety, clinical outcome and patients' experience of a FT programme after pancreaticoduodenectomy (PD) in a high-volume institution in Sweden.