Pituitary Adenylate Cyclase Activating Peptide (PACAP): An Experimental Study On the Expression and Regulation in the Peripheral Nervous System.
This thesis deals with PACAP and PACAP type-1 receptors in the sensory and autonomic parts of the peripheral nervous system. In the rat, PACAP is expressed in small-sized sensory neurons and in C-fibers. Unilateral transection of the sciatic nerve (axotomy) causes an upregulation of PACAP in medium-sized and large neurons, whereas the density of PACAP-IR fibers is decrea sed in the dorsal horn. In