Background & Aims: Biomarkers are needed to identify individuals at elevated risk of inflammatory bowel disease. This study aimed to identify protein signatures predictive of inflammatory bowel disease. Methods: Using large population-based cohorts (n ≥180,000), blood samples were obtained from individuals who later in life were diagnosed with inflammatory bowel disease and compared with age a

Photoacoustic imaging can potentially map oxygen saturation (sO2) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of chromophore concentrations deep in tissue. This study compares the performances of two previously proposed methods for spectral coloring compensation

Surface-enhanced Raman scattering (SERS) technology can detect molecular information; Because of its high sensitivity, it is widely used in chemical analysis. In this study discussed the experimental detection of 1,4-diethynylbenzene molecule based on SERS technology. The SERS spectra of 1,4-diethynylbenzene molecule were calculated by Density Functional Theory (DFT) simulation, and the results sh

Due to the large extent of seawater surface over the globe, aerosol particles spend significant time being transported over this type of surface. Therefore, global aerosol circulation is largely impacted by the processes particles undergo during long-range transport overseas. In this study, we investigated submicron aerosol (PM1) chemical composition changes during long-range transport events over

Background: The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes. Methods: Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrat

This document has been developed to provide practical resources to policymakers, institutional representatives, and educators, by offering a diverse range of examples and recommendations at various levels to support the implementation and enhancement of ISE.The White Book is founded on the theoretical framework of ISE developed throughout the Communities or Sciences (C4S) Towards Promoting an Incl

Background: Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 protein are being developed. However, it is unknown what the effect of TREM2 variants is on the AD phenotype. Methods: Here we studied a full range of clinical and biomarker measures in a large cohort of TREM2 variant carr

Patients with systemic lupus erythematosus (SLE) face an approximately 30 % risk of thrombosis post-diagnosis. However, there remains significant knowledge gaps regarding causative mechanisms, and there is a lack of specific antithrombotic guidelines. This systematic review aims to examine the existing literature regarding the mechanisms contributing to thrombosis risk in SLE, focusing on five pre

Intrauterine fetal programming determines cardiorenal interaction later in life. We hypothesize that early life factors affect adult glomerular filtration rate and mean arterial pressure (MAP) directly or by interacting with postnatal growth trajectories. The population-based LifeGene study (Sweden) randomly recruited individuals aged 18 to 43 years (n = 12 167). They filled in a web-questionnaire

Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient

Denna uppsats analyserar det svenska anställningsskyddet ur ett historiskt perspektiv från 1833 års legostadga till dagens arbetsrättslagstiftning (Prop. 2021/22:176). Uppsatsens huvudfokus ligger på kraven för att en uppsägning ska vara giltig (7 § LAS) och turordningsbestämmelser vid arbetsbrist (22 § LAS). Anställningsskyddet har genom historien gått i vågor mellan starkt skydd och svagt skyd

This thesis explores the Value Added Tax (VAT) treatment of vouchers within the framework of the EU’s Voucher Directive, with a particular focus on its application to discount vouchers, city cards, and VAT special schemes. The Voucher Directive has been implemented to harmonize and clarify the VAT treatment of vouchers across Member States including distinctions between single-purpose and mult

The concept of ‘eco-anxiety’ has increasingly gained traction both in media and academia, with climate activists hypothesised as prone to experiencing it. However, humour has for long been a crucial aspect of social movements, and it holds strong potential in adaptively coping with stressors. Therefore, this thesis aims to describe climate activists’ emotional experiences characterised as eco-anxi

The increasing frequency of facade fires, often exacerbated by combustible cladding systems, has emphasized the need for passive fire protection strategies. Among these, horizontal projections—such as balconies, canopies, and deflectors—have emerged as potential fire safety elements. This thesis investigates the influence of horizontal projections on thermal exposure and lateral flame spread acros

Den svenska partipolitiken kännetecknades länge av en tydlig klassdiskurs, och ansågs vara undantaget för nedgången i den klassbaserade röstningen. Under de senaste decennierna har däremot även Sverige genomgått förändringar i den klassbaserade röstningen där arbetarklassens väljare alltmer förflyttats från socialdemokratin till högernationalistiska partier. Följande undersökning avser därför att

A fluid and undefined existence that tears in all directions, a total chaos swirling like a storm that diminishes the recognisable, creating confusion and disorientation. The question is whether to shape something in the outer, or whether something in the outer should be allowed to shape the inner: to let oneself be shaped by what is external, or to let what is external shape the internal. The two

We present recent results in the field of total binding energy calculations, Landщ factors, quantum electrodynamics corrections and lifetime that are of interest for ion traps and ion sources. We describe in detail MCDF and RMBPT calculation of ionic binding energies, which are needed for the determination of atomic masses from highly charged ion measurements. We also show new results concerning L

Diplomonads are anaerobic, flagellated protists, being part of the Metamonada group of Eukaryotes. Diplomonads either live as endobionts (parasites and commensals) of animals or free-living in low-oxygen environments. Genomic information is available for parasitic diplomonads like Giardia intestinalis and Spironucleus salmonicida, while little is known about the genomic arrangements of free-living