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Purpose: Personalized therapies are leading to an increasing number of marketing authorizations based on single-arm trials, which increases the demand for better post-authorization monitoring strategies. The aim of the present study was to estimate the power over time as data accrue in population-based registries for detecting deviations from the expected efficacy/safety of chimeric antigen recept

Introduction: We aimed to establish a standardized, routine-use pre-analytical protocol for measuring Alzheimer's disease (AD) biomarkers in cerebrospinal fluid (CSF). Methods: The effect of pre-analytical factors (sample collection/handling/storage/transportation) on biomarker levels was assessed using freshly collected CSF. Tube type/sterilization was assessed using previously frozen samples. A

Aim: To test whether diabetes genetic risk modifies the association of successful lifestyle changes with incident diabetes. Materials and methods: We studied 823 individuals randomized to the intensive lifestyle intervention (ILS) arm of the Diabetes Prevention Programme who were diabetes-free 1 year after enrolment. We tested additive and multiplicative interactions of a 67-variant diabetes genet

At the 100 years anniversary in 2020 of the Reunion around 650 memorials have been protected. The memorials are to be found all over Denmark, where they constitute the largest group. The time of their erection, the localization, design, inscriptions, pictures and initiators are relatively well known. The article investigates two main questions. Firstly, why have so many memorials for the Reunion bAt the 100 years anniversary in 2020 of the Reunion around 650 memorials have been protected. The memorials are to be found all over Denmark, where they constitute the largest group. The time of their erection, the localization, design, inscriptions, pictures and initiators are relatively well known. The article investigates two main questions. Firstly, why have so many memorials for the Reunion b

Parallelism is here to stay. Unfortunately, today’s mainstream programming languages (such as Java) are not designed for easy parallelisation. We thus propose to extend Java with primitives for parallel queries, using a radically redesigned Java runtime system.

Software bugs cost time, money, and lives. They drive software research and development efforts, and are central to modern software engineering. Yet we lack a clear and general definition of what bugs are. Some bugs are defects, clearly defined as failures to meet some requirement or specification. However,there are many forms of undesirable program behaviour that are completely compatible with a

Objective: Prevalence of stunting is frequently used as a marker of population-level child undernutrition. Parental height varies widely in low- and middle-income countries (LMIC) and is also a major determinant of stunting. While stunting is a useful measure of child health, with multiple causal components, removing the component attributable to parental height may in some cases be helpful to ide

INTRODUCTION: Both echocardiography and CMR imaging are used to quantify longitudinal function. Inter-method variability for mitral (MAPSE) and tricuspid (TAPSE) annular plane systolic excursion, and variability between directly measured MAPSE and TAPSE and as based on atrio-ventricular plane displacement (AVPD) analysis by CMR, are however not known. This study therefore assessed inter-method var

The city of Moscow has been going through a transformation of its surface transport network during the past decade as part of a broader policy of urban beautification. Despite a renewed interest in public transport, this policy has led to the dismantling of the trolleybus system. This was met with resistance from various groups. Bringing together scholarly discussions on urban growth coalitions an

AIM: Traditional methods used when managing self-harm in a psychiatric inpatient setting tend to infringe on the autonomy of the individuals receiving treatment and are often experienced as practically and emotionally challenging by care providers. Therefore, we examined care providers' experiences of an alternative method negotiating self-harm abstinence agreements, which can be viewed as a form