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Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (PD). However, there is no direct evidence in humans to support this role1–5. In this study, we used dynamic contrast-enhanced magnetic resonance imaging to assess meningeal lymphatic flow in cognitively normal controls and patients with idi
Despite the availability of methods for analyzing protein complexes, systematic analysis of complexes under multiple conditions remains challenging. Approaches based on biochemical fractionation of intact, native complexes and correlation of protein profiles have shown promise. However, most approaches for interpreting cofractionation datasets to yield complex composition and rearrangements betwee
Root exudates can significantly modify microbial activity and soil organic matter (SOM) mineralization. However, how root exudates and their C/N stoichiometric ratios control paddy soil C mineralization is poorly understood. This study used a mixture of glucose, oxalic acid, and alanine as root exudate mimics for three C/N stoichiometric ratios (CN6, CN10, and CN80) to explore the underlying mecha
We present Higher Order Mode (HOM) studies on ESS Medium-Beta cavity, designed in INFN-LASA, including both simulation and measurement results. Mechanical tolerances of the fabrication process might shift HOMs frequencies toward harmonics of the bunch frequency. Both simulation and measurements at room and cryogenic temperature show that the design is fully compatible to requirements.
BACKGROUND: Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of incident IBD is still unexplored. This study aimed to investigate the association of serum ZRP levels with both prevalent and incident IBD.METHOD: The study included a total of 1
We present a solution for long-term direct current resistivity and time-domain induced polarization (DCIP) monitoring, which consists of a monitoring system and the associated software that automates the data collection and processing. This paper describes the acquisition system that is used for remote data collection and then introduces the routines that have been developed for pre-processing of
Electrical Resistivity Tomography (ERT) and Transient ElectroMagnetic sounding (TEM) is used for aquifer mapping in Bolivia. The results demonstrate the value of using geophysics in hydrogeological investigations of quaternary deposits, and that the methods are complementary so that the combination is beneficial. ERT produced highly useful results for delineating the aquifer geometry and internal
Objective Deconvolution is an ill-posed inverse problem that tends to yield non-physiological residue functions R(t) indynamic susceptibility contrast magnetic resonance imaging (DSC-MRI). In this study, the use of Bézier curves is proposedfor obtaining physiologically reasonable residue functions in perfusion MRI.Materials and methods Cubic Bézier curves were employed, ensuring R(0)=1, bounded-in
