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Cancer is a highly heterogeneous disease caused by dysregulation in different cell types and tissues. However, different cancers may share common mechanisms. It is critical to identify decisive genes involved in the development and progression of cancer, and joint analysis of multiple cancers may help to discover overlapping mechanisms among different cancers. In this study, we proposed a fusion f

Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake and related systemic metabolic statuses. Glutamatergic neurotransmission plays a major role in the regulation of excitatory tones in the central nervous system, although just how dietary elements contribute to the tuning of this system remai

Background: Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. We hypothesize that appropriate mechanotransduction and contractile function in vascular smooth muscle cells are crucial to maintain vascular wall integrity. The Hippo pathway effectors YAP (yes-associated protein 1) and TAZ (WW domain containing transcription re

This study aims to verify the nutritional value of the fatty acid (FA) profile of three fruits claimed to confer health benefits (goji berry, white mulberry, and cranberry), often referred to as “superfruits”, over three common fruits (banana, apple, and strawberry). Nineteen different FAs, ranging in concentrations between 0.018 and 9.4 mg/g dry sample were detected. Levels of very long-chained F

Predictions of cloud droplet activation in the late summertime (September) central Arctic Ocean are made using κ-Kohler theory with novel observations of the aerosol chemical composition from a high-resolution time-of-flight chemical ionization mass spectrometer with a filter inlet for gases and aerosols (FIGAERO-CIMS) and an aerosol mass spectrometer (AMS), deployed during the Arctic Ocean 2018 e

We are surrounded by various chemicals, both naturally occurring and synthetically produced. Some, but not all, chemicals can be hazardous for human health following exposure, especially for vulnerable population groups including children, adolescents, and pregnant women. The increased use and production of chemicals have contributed positively to society in numerous ways, while also resulting in

The lack of effective, scalable solutions for lifestyle treatment is a global clinical problem, causing severe morbidity and mortality. We developed a method for lifestyle treatment that promotes self-reflection and iterative behavioral change, provided as a digital tool, and evaluated its effect in 370 patients with type 2 diabetes (ClinicalTrials.gov identifier: NCT04691973). Users of the tool h

Stressful or traumatic memories of an intensive care stay may lead to long-term psychological morbidity. Memory assessment is therefore essential to aid in the patients’ recovery process. Acknowledging the large cohort of post ICU patients during the SARS-CoV-2 pandemic, a simple tool for the evaluation of ICU memories is needed. The aim of this study was, therefore, to develop and test the validi

Adverse childhood experiences (ACE) and high levels of disinhibition have been associated with a variety of negative outcomes such as aggressive antisocial behavior (AAB). However, forensic psychiatric populations remain an understudied group in this field of research. This study aimed to fill that gap by investigating associations between ACE, AAB, and disinhibition in a forensic psychiatric samp

Cities have an important role to play in implementing the UN Sustainable Development Goals (SDGs) and to mobilize sustainability at the urban level. Yet, municipalities encounter challenges in localizing the SDGs into their governance structures, and there is a need to advance our understanding of cities strengths and weaknesses in such processes. In this article we provide knowledge and reflectio

One major risk threatening embankment dam integrity is internal erosion of the core. Internal erosion progresses inside the dam but it is difficult to detect with conventional methods. Electrical Resistivity Tomography (ERT) is a potential-based method that can sense the interior of the dam, and this study aims to evaluate the capability of ERT as a complementary monitoring technique for discoveri

An appropriate and stable indoor climate in museums is crucial to guarantee an appropriate preservation of our cultural heritage. Depending on the collection, indoor temperature and relative humidity need to be kept within a certain range. Fluctuations in temperature and relative humidity could cause damage to museum artefacts and may require higher energy needs than necessary. Biochar is a materi

Motivation in simultaneous L2 learning situations is an area of research largely overlooked and studies from contexts where people are engaged in learning more than one L2 are rare. In their large-scale Hungarian research, Dornyei, Csizer and Nemeth found that pupils' positive attitudes to one L2 could cause interferences with attitudes to others, with English being the greatest source of such int

How does elite communication influence affective polarization between partisan groups? Drawing on the literature on partisan source cues, we expect that communication from in- or outgroup party representatives will increase affective polarization. We argue that polarized social identities are reinforced by partisan source cues, which bias perceptions of elite communication and result in increased