Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes

The exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some currenThe exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some curren

BACKGROUND: Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical barriers and costs of implementing such assays at scale. To overcome these challenges, we used a "virtual proteomic" approach, linking genetically predi

Purpose: Forensic populations have high prevalence rates of adverse childhood experiences (ACE), but specific pathways from childhood victimization to adult victimizing behavior remain unclear. Difficulties in emotion regulation may prove to be a more proximal risk factor that functions as a pathway between ACE and aggressive antisocial behavior (AAB). In this study, we investigated concurrent ass

Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreatic beta cells is unidentified. We used RNA sequencing of Cartpt knockdown (KD) INS-1 832/13 cells and identified GPR162 as the most Cartpt-regulated receptor.

Acute-phase inhibition of the pro-inflammatory alarmin S100A8/A9 improves cardiac function post-myocardial infarction (MI), but the mechanisms underlying the long-term benefits of this short-term treatment remain to be elucidated. Here, we assessed the effects of S100A8/A9 blockade with the small-molecule inhibitor ABR-238901 on myocardial neovascularization in mice with induced MI. The treatment

The research presented here explores the nuances of data collection and sharing via digital platforms in everyday CrossFit coaching practice. There is a growing body of work on data and digital platforms in CrossFit, though currently there is a lack of research on the role of coaches in these processes. Empirically grounding the digital fitness practices of CrossFit coaching is essential for our u

The association between higher education and political attitudes is well-recognized, and research suggests that socialization amongst peers is one of the most probable mechanisms explaining a possible attitudinal change. However, identifying a socialization effect is difficult due to self-selection mechanisms and limitations in data availability. This article empirically investigates the underlyin

Increased global migration to welfare states puts pressure on successful integration. Successful integration is broadly associated with entry into the labour market. Therefore, integration is measured through employment. Attempts to increase migrant involvement in the labour market are often made by street-level organisations, where interactions between individuals from the private and/or public s

Ambulance travel time estimations play a pivotal role in ensuring timely and efficient emergency medical care by predicting the duration for an ambulance to reach a specific location. Overlooking factors such as local traffic situations, day of the week, hour of the day, or the weather may create a risk of inaccurately estimating the ambulance travel times, which might lead to delayed emergency re

Introduction: The impact of moderate haemophilia on health-related quality of life (HRQoL) and physical activity (PA) is not well known. In previous studies, persons with factor VIII/factor IX activity (FVIII/FIX:C) below 3 IU/dL were associated with a more severe bleeding phenotype than predicted. Aim: To explore HRQoL and PA in patients with moderate haemophilia A (MHA) and B (MHB). Methods: A c

Objective(s): Nitrite, a nitric oxide (NO) donor, increases insulin secretion from pancreatic islets and has positive metabolic effects in type 2 diabetes (T2D). Here, we test the hypothesis of whether nitrite-induced insulin secretion is due to blunting of diabetes-induced oxidative stress in the islets. Materials and Methods: T2D was created in male rats using a combination of streptozotocin at

Motivation in simultaneous L2 learning situations is an area of research largely overlooked and studies from contexts where people are engaged in learning more than one L2 are rare. In their large-scale Hungarian research, Dornyei, Csizer and Nemeth found that pupils' positive attitudes to one L2 could cause interferences with attitudes to others, with English being the greatest source of such int