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Reduced insulin release has been linked to defect exocytosis in β-cells. However, whether expression of genes suggested to be involved in the exocytotic process (exocytotic genes) is altered in pancreatic islets from patients with type 2 diabetes (T2D), and correlate to insulin secretion, needs to be further investigated. Analysing expression levels of 23 exocytotic genes using microarray revealed

Little is known about the nature of post mortem degradation of proteins and peptides on a global level, the so-called degradome. This is especially true for non-neural tissues. Degradome properties in relation to sampling procedures on different tissues are of great importance for the studies of for instance post translational modifications and/or the establishment of clinical biobanks. Here, snap

Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis pat

This thesis analyses the development of ethics committees from a sociology of law perspective and a social steerage perspective ("social control"). The main question is: Why are ethics committees established? Institutionalised ethics committee is a rather new phenomenon, which has become widely spread in the last 20 years. The study points out the public ethical debate since the 1980s as a major e

Value Based Management (VBM) has become a common tool for evaluating corporate strategies and projects from the perspective of shareholder value maximization, and can be an important input for corporate compensation systems. But traditional VBM frameworks make no systematic effort to distinguish between changes in performance attributable to macroeconomic fluctuations beyond management's control a

I here propose a modification of the English butterfly census method (Pollard 1977) for studies of large areas with a relatively low density of butterflies. The transect line should not be more than 10 m from any point in open terrain and open forests, but only 5 m from sunny edges and patches with a high density of flowers. The transect line is adjusted between visits to most intensively cover si

Objective-To compare four different inception cohorts of patients with early rheumatoid arthritis (RA) with respect to treatment strategies, disease activity, and outcome during a five year follow up period. Method-Data from cohorts of patients with early RA, with a standardised assessment at least every six months for five years from four different centres, were included in one database. Owing to

Background: Studies during the 1990s showed that it was possible to reduce the rate of negative appendectomies by using various diagnostic methods. The present study aims to evaluate the effect on diagnostic accuracy of implementation of repeated clinical examination and blood tests in a small county hospital without possibilities of radiological assistance on a 24-hour basis. Methodology: Prospec

The aim of this thesis was to investigate older people's views and experience of prioritisation and resource allocation in health care, which is important because older people are the group that use public health care and service most. The aim was also to investigate differences in the view of prioritisation and resource allocation in relation to age, gender, housing, health-related quality of lif