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Adipose tissue plays a major role in regulating whole-body energy metabolism. While the biochemical processes regulating storage and release of excess energy are well known, the temporal organization of these events is much less defined. In this study, we have characterized the presence of small surface-associated lipid droplets, distinct from the central droplet, in primary human adipocytes. Base
The new estimates of the Maddison Project show that the p.p.p. GDP per capita ratio between Bolivia and Finland has changed from 0.68 ca. 1850 to 0.16 in 2015; similarly, that between Chile and Norway from 0.65 to 0.28. The aim of this article is to present a review of the literature and available quantitative evidence to understand how these extreme differences became possible between countries w
This paper examines the short-term effect between take-up of Social Assistance Benefit (SAB) and mental health. Using a panel dataset including rich yearly register data on e.g. income, income sources, unemployment and types of pharmaceutical consumption for over 140,000 Swedes 2006-2012, we quantify the importance of the psychosocial dimensions (e.g. shame and guilt) of the socioeconomic status –
Orthostatic hypertension, which appears to be mediated through excess neurohumoral activation while standing, is a common blood pressure trait among patients with and without arterial hypertension. However, lack of consensus regarding the definition of orthostatic hypertension makes it difficult to assess the true prevalence of this condition. Orthostatic hypertension appears to predict the risk f
Walking is an important transport mode for sustainable cities, but the usability of pedestrian environments for people with impaired vision is very limited after dark. This study compares the usability of a walkway, operationalized in terms of (i) the pedestrian's ability to orient themselves and detect infrastructure elements, and (ii) the perceived quality of lighting in the environment (evaluat
In order to meet the EU's climate and resource efficiency targets, changes in our daily-life behaviours, as well as business models, are urgently necessary. More insights are needed to make real changes based on research with a systems perspective. We developed a system dynamics model to analyse the environmental benefits of a transition from ownership-based to access-based household laundry activ
Vid kronisk myeloisk leukemi har målstyrd, kontinuerlig behandling med tyrosinkinashämmare lett till dramatiskt förbättrad överlevnad. Efter ett flertal år uppnås djupt molekylärt svar hos ca 50 procent av patienterna; ca 50 procent av dem kan då avbryta behandlingen utan tecken på återfall. Kontinuerlig behandling med tyrosinkinashämmare kan ge långsiktiga biverkningar. Efter patentutgång för imaChronic myeloid leukemia - a model disease for targeted therapy Chronic myeloid leukemia (CML) pioneered as the first human malignancy linked to a specific cytogenetic aberration (the Philadelphia chromosome), which led the way to specific targeted therapies with imatinib (Glivec) and later tyrosine kinase inhibitors (TKI). Continuous TKI administration, blocking the oncogenic fusion protein Bcr-A
Unbiased, “nontargeted” metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFL
Walking as a means of transportation is a key feature in sustainable urban design, but few studies have examined the influence of micro-level environmental features, such as vegetation and street lighting, on perceived safety and people’s choice to walk. This study applied a non-explicit approach to examine the relationship between greenery, street lighting, perceived safety, and walking in an urb
Policy for science, technology, and innovation is increasingly supporting bottom-up approaches to setting strategic agendas for research and innovation (R&I). These processes are designed to bring industrial needs of R&I intensive sectors to the fore, while at the same time stimulating engagement of other relevant stakeholders, such as public and private research performers. This paper add
This article draws on empirically derived illustrations of return to work and unemployment to critically explore how a narrow understanding of work pervades contemporary social policies and programmes. This is particularly relevant in economic and labour market transitions aligned with neoliberalism that individualise the social problem of unemployment and thus restrict occupational possibilities
Previous research indicates that exporting firms are willing to pay a premium to poach workers from other exporting firms if experience working for an internationally engaged firm reduces trade costs. Since international experience is less valuable to non-exporters, we would expect to see differences in recruitments between firms that are internationally engaged and those that serve only their dom
Safety in density (SID) potentially explains the safety in numbers (SIN) phenomenon by positing that ‘the SIN effect can be reproduced simply through encouraging behaviour that leads to the formation of higher-density cyclist groups’. The study further explores this hypothesis using event-based exposure, queues and groups of road users. Using three different definitions of encounters between road u
Lichens of the genus Cladonia, mainly C. alpestris, collected during 1882-1972 were analyzed for stable lead and 210Pb. The specific activity of 210Pb (210Pb/Pb ratio) indicates a constant value of about 2 mCi/kg up to 1940, and then decreased to 0.6 mCi/kg during 1950-1960. As the average annual 210Pb deposition is relatively constant, the decrease in the 210Pb/Pb ratio after 1940 indicates an in
