In order to investigate whether oxidative damage is associated with differences in antioxidant intake, we measured the levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in lymphocytes and α-tocopherol and several carotenoids in plasma of women with different dietary habits. We found that women from Granada (Spain), a region with a typically Mediterranean diet, had significantly higher leve

Despite the fact that Cesarean section (C-section) is the most commonly performed surgery in a number of industrialized countries, little is known about the long-term consequences for the mothers and children involved. In this study, I use a sample of high-risk births—namely, breech births, in which the fetus is presented with its head upward instead of downward—to study the causal effect of C-sec

The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disruption of E2-2 and HEB results in failure to express the early lymphoid program in Co

Background: The aim was to determine prevalence and age at seroconversion of thyroid autoimmunity in relation to islet autoantibodies, gender and HLA-DQ genotypes in children with increased risk for type 1 diabetes followed from birth. Methods: In 10-year-old children (n = 1874), blood samples were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid

Progression to clinical type 1 diabetes varies among children who develop b-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar profiles associated with various types of progression among 600 children from The

Constructing in rock will always involve unforeseen rock conditions. This involves a large risk to a project and can in the end entail delays and extra costs. To minimize the risks, an optimized pre-investigation program has to be conducted where essential information is gathered in order to make the best decisions throughout the construction project. In this work the main focus has been on the ap

Although grade inflation is unfair and may imply inefficient allocation of human resources, current knowledge of grade inflation effects on individual outcomes is scarce. One explanation is probably the challenge of measuring and estimating causal grade inflation effects. This study examines the consequences of grade inflation at the upper secondary education level on enrolment in higher education

Urban Living Labs (ULL) are considered spaces to facilitate experimentation about sustainability solutions. ULL represent sites that allow different urban actors to design, test and learn from socio-technical innovations. However, despite their recent proliferation in the European policy sphere, the underlying processes through which ULL might be able to generate and diffuse new socio-technical co

In North Sámi, inceptives can be formed with the inceptive verb álgit, with the morphologically bound form -goahtit, or by changing the theme vowel of the base verb. The syntactic properties of these inceptives indicate that -goahtit is an auxiliary, and so is álgit when it takes a verbal complement. These inceptive auxiliaries are located below tense, and also below obligational and permissive mo

Conventional road accident risk is measured by the undesirable events/exposure ratio. Common exposure indicators are activity-based, so event-based exposure is needed to achieve event-based safety assessment. Furthermore, road safety simulation is a growing research field. The influence of some software parameters is still unknown. Besides, the use of simulation for exposure assessment is incipien

The intestine and the brain are connected via the brain-gut axis and the intestinal microbiota influences the immune activation and signaling molecules that are involved in the stress response. The aim of the study was to investigate if intake of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) for four weeks could counteract elevated cortisol and inflammation levels in subjects

Background Differentiating between pneumonia and acute bronchitis is often difficult in primary care. There is no consensus regarding clinical decision rules for pneumonia, and guidelines differ between countries. Use of diagnostic tests and change of management over time is not known. Aim To calculate the proportion of diagnostic tests in the management of lower respiratory tract infections (LRTI

We all need to contribute to a more sustainable development – a fact that has become quite clear observing extreme weathers and diminishing fossil fuel sources. In line with the 12 Principles of Green Chemistry [1], (recommending the use of safer solvents, catalysed reactions, energy efficient processes and renewable feedstocks), research within the SuReTech program aims at developing technologies