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Dipeptidyl peptidase-4 (DPP-4) inhibition is a glucose-lowering medication for type 2 diabetes. It works through stimulation of insulin secretion and inhibition of glucagon secretion in a glucose-dependent manner, resulting in lowered fasting and postprandial glycemia with low risk of hypoglycemia. As impaired insulin secretion and augmented glucagon secretion are key factors underlying hyperglyce
Mammalian metabolism comprises a series of interlinking pathways that include two major cycles: the folate and methionine cycles. The folate-mediated metabolic cycle uses several oxidation states of tetrahydrofolate to carry activated one-carbon units to be readily used and interconverted within the cell, which are required for nucleotide synthesis, methylation and metabolism, particularly for pro
Backgroundamong the 1–1.5 billion persons with hypertension globally only, 20–30% have controlled blood pressure (BP). The most important problem identified is non-adherence to treatment, i.e., failure to change lifestyle and to take prescribed medication. Knowledge about the reasons for this is limited.ObjectivesThe aim of the study was to explore people's experiences of having hypertension.Desig
Today, more than half of the world’s population live in cities, and by mid-century it is predicted that more than two-thirds of the world’s population will live in urban areas. This sees cities at the forefront of sustainability, needing to meet social needs within our ecological boundaries. An overarching guiding roadmap to consider sustainability is the United Nations’ Sustainable Development Go
Popular Abstract in Spanish Resumen En esta tesis se describe el desarrollo y la posterior aplicación en el aula de los Modelos Didácticos del Subjuntivo 1 y 2, cuyo mecanismo se centra en la utilización de una pregunta con la cual el estudiante podrá hacer la elección modal más adecuada para cada caso. El modelo unifica conceptos y valores adjudicados al subjuntivo y presenta la gramática desde uAbstract In the present thesis the development and subsequent implementation of the Didactic Models 1 and 2 of the Subjunctive is described. The models focus on the use of a question, with which the student makes the most adequate mode choice for each case. The model unifies perspective and meaning used with the subjunctive from a cognitive perspective, appealing to the inherent representational c
IT procurement represents a business process of high importance, including the ability to articulate requirements that the procurement deals with. Furthermore, specifying requirements is of importance for both procurer and potential supplier, as it functions as central contractual element between the two. The purpose of this article is two-fold: (i) to show how established terminology for requirem
PURPOSE: To investigate the role that both patient and outpatient factors related to health care practice (HCP) play in physicians' early adoption of rosuvastatin. MATERIALS AND METHODS: Generalized estimation equations (GEEs) and alternating logistic regression (ALR) with pair-wise odds ratios (PWORs) were used to measure similarities in rosuvastatin prescription within HCPs for all individuals w
In North Sámi, inceptives can be formed with the inceptive verb álgit, with the morphologically bound form -goahtit, or by changing the theme vowel of the base verb. The syntactic properties of these inceptives indicate that -goahtit is an auxiliary, and so is álgit when it takes a verbal complement. These inceptive auxiliaries are located below tense, and also below obligational and permissive mo
The aim of this study was to investigate the prevalence of extended-spectrum beta-lactamase (ESBL)-producing bacteria in patients at various hospital wards and in a group of relatively healthy volunteers, in order to obtain greater knowledge on how common these bacterial strains are in hospital settings and in the general community. Participants (n = 427) were enrolled at a University Hospital and
Stage models were prevalent in developmental psychology in the past, but have recently been subjected to much criticism. We propose “rehabilitation”, defining semiotic stage as a (not necessarily stable) period characterized by the clear establishment of a novel semiotic capacity, which may “dominate” the communication of the child at this stage, but does not replace capacities from previous
TV-on-Demand service has become one of the most popular Internet applications that continuously attracts higher user interests. With rapidly increasing user demand, the existing network conditions may not be able to ensure low start-up delay of video playback. Prefetching has been broadly investigated to cope with the start-up latency problem which is also known as user perceived latency. In this
Intag av söta livsmedel har ökat i Sverige och övriga västvärlden. Typ av söta livsmedel har också ändrat karaktär; sött finns idag främst som dryck – läskkonsumtionen står i särklass över andra söta drycker. Aptitreglering för socker har beskrivits i djurmodeller, där det visats att opiatfrisättning triggar sockerintag i en uppåtgående spiral. Troligen gäller samma för människa. Sött frisätter op
OBJECTIVE : To identify predictors of later study withdrawal among participants active in The Environmental Determinants of Diabetes in the Young (TEDDY) for 1 year. METHODS : Multiple logistic regression was used to discriminate 3,042 children active in TEDDY for the first 3 years from 432 children who withdrew in Years 2 or 3. Predictor variables were tested in blocks-demographic, maternal lifes
