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BACKGROUND AND AIMS: Autoantibodies against the zinc transporter 8 (ZnT8A) are common in type 1 diabetes (T1D). ZnT8A analyses are complicated by the fact that there are three variants of the autoantigen at amino acid position 325 representing ZnT8-R (Arginine), ZnT8-W (Tryptophan) and ZnT8-Q (Glutamin). The aims of the study were: 1) to develop an autoantigen triple mix Radio-Binding Assay (RBA)

A study of the ambitions of the managers at AB Robertsfors Bruk and their impact on courses of action in the development of wage policy and social arrangements in the community of Robertsfors during the period 1925-35.This study deals with employer actions during a period of both internal and external change to the organization. The main focus is in the areas of wage policy and social arrangements

AIMS/HYPOTHESIS: The aim of this study was to ascertain whether treatment of GAD65 autoantibody (GADA)-positive diabetic patients with alum-formulated recombinant GAD65 (GAD-alum) is safe and does not compromise beta cell function. METHODS: This Phase 2, placebo-controlled, dose-escalation clinical trial, which was randomized through a central office, was performed in 47 GADA-positive type 2 diabe

French is characterized by major differences between phonology and orthography. Consequently, learning the deep orthography of written French is a challenge to both first (L1) and second (L2) language learners. This empirical study focuses on the production of silent number morphology in written French and illustrates that a group of L2 learners, exposed to limited amounts of spoken French in a ty

Venous thromboembolism (VTE) is a relatively common cause of morbidity and mortality. It has an annual incidence of around 0.1- 0.3%. It is a multifactorial disease with many known risk factors, both transient and persistent. Among these, several genetic risk factors have been described. The most common genetic risk factor, factor V Leiden mutation in heterozygote form, is found in 5-8% of the Cau

Genetisk rådgivning (vägledning) etablerades inom svensk sjukvård under 1960- och 1970-talet. Samtidigt stärktes föreställningen om individens självbestämmande i reproduktiva frågor, en uppfattning som hade börjat formuleras redan under 1950-talet. I artikeln diskuteras hur den genetiska rådgivningen som tidigare baserats på empiriska riskberäkningar under 1960- och 1970-talet fick en delvis annan

This introduction positions the essays in this special issue in relation to Pascale Casanova’s model of inequality and value in the world republic of letters. Arguing that the vernacular has been an overlooked or underelaborated concept in subsequent world literary theorizations, the essay then proceeds to discuss the shifting value and nature of the vernacular–a concept that only has meaning if i

Introduction: Detection of circulating tumour cells (CTCs) in peripheral blood has an established prognostic significance in patients with metastatic breast cancer. Change in the number of detected CTCs is also an indication of response to therapy. Characterisation of CTCs could provide easily accessible treatment predictive information of present cancer cells within the patient and could reveal i

ALS is characterized by the degeneration of upper and lower motor neurons. In about 70% of patients with ALS the disease has an spinal onset, while about 30% of the patients have a bulbar onset. Cognitive dysfunction and behavioral changes are seen in about 50% of the patients, and 15% develop frontotemporal dementia. There is no single test that provides the ALS diagnosis. The diagnosis is based

Background: Advanced glycation end-products (AGEs) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the association between AGE accumulation in the skin measured by skin autofluorescence (SAF) and lung function in healthy subjects has not been explored in detail. We use a population-based study of 50-64-year-olds to assess spirometry, diffusing