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Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (valida

Little is known about the demographic/life-style/physiological determinants explaining the variation of serum perfluoroalkyl acid (PFAA) concentrations in children. We identified significant determinants in children and investigated the influence of low-level PFAA-contaminated drinking water (DW) (<10 ng L-1 of single PFAAs) on serum concentrations. Four perfluorosulfonic acids (PFSAs) and 11 perf

Background: Diet is a determinant of gut microbiota. Both diet and gut microbiota have been linked to metabolic diseases. Objective: We aimed to examine data-driven food patterns in relation to the prevalence of prediabetes and gut microbiota composition and food pattern-associated bacteria in relation to prediabetes. Methods: Food patterns were extracted using principal component analysis in 1726

This introduction positions the essays in this special issue in relation to Pascale Casanova’s model of inequality and value in the world republic of letters. Arguing that the vernacular has been an overlooked or underelaborated concept in subsequent world literary theorizations, the essay then proceeds to discuss the shifting value and nature of the vernacular–a concept that only has meaning if i

Introduction: Detection of circulating tumour cells (CTCs) in peripheral blood has an established prognostic significance in patients with metastatic breast cancer. Change in the number of detected CTCs is also an indication of response to therapy. Characterisation of CTCs could provide easily accessible treatment predictive information of present cancer cells within the patient and could reveal i

ALS is characterized by the degeneration of upper and lower motor neurons. In about 70% of patients with ALS the disease has an spinal onset, while about 30% of the patients have a bulbar onset. Cognitive dysfunction and behavioral changes are seen in about 50% of the patients, and 15% develop frontotemporal dementia. There is no single test that provides the ALS diagnosis. The diagnosis is based

Background: Advanced glycation end-products (AGEs) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the association between AGE accumulation in the skin measured by skin autofluorescence (SAF) and lung function in healthy subjects has not been explored in detail. We use a population-based study of 50-64-year-olds to assess spirometry, diffusing

Naturally occurring uranium is known to give rise to adverse renal effects in various species after ingestion. This short review of uranium toxicity focus on three epidemiological studies on drinking water which are compared with a pivotal study in experimental animals used as a basis for limits of uranium in drinking water or guidelines in several countries. These studies are scrutinized and disc

The Social Services Acts’ Value System – An Analyze of its Practical Meaning in Social Investigations on Children This article discusses the relation between legal and practical norms, on the basis of a model over the norms main components. The focus is on the norms value component, and the question is how the value of a legal norm is implemented in that practice which the norm is aimed to regula

There are many market and organisational barriers to the breakthrough of a new industrial field such as bioenergy. For many observers, recent high prices of oil and the significant policy support measures throughout Europe, would appear to have created economic conditions that should be sufficient for the industry to prosper. However, a significant number of policies supposed to expand bioenergy (

Special issue on crime fiction film & tv. Contents: Editorial (Michael Tapper), Not "Another Bloody Cop Show": Life on Mars and British Television Drama (James Chapman), Clowns, Crimes and Capital: Popular Crime-Comedies in Post-Crisis Korea (Jinying Li), "It's a Fine Line Between Safety and Terror": Crime and Anxiety Re-Drawn in Spooks (Paul Cobley), Buddies, Bitches, Broad: The British Femal