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This thesis explores the use of data mining and AI-tailored frameworks for extracting public health evidence from large health datasets. The research presented in this thesis demonstrates the potential of these tools for automating and simplifying the data mining process, and for providing valuable insights into various public health issues.In Paper I, we used data mining and natural language proc

BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.METHODS: We conducted a cross-sectional study of 8973 participants (50

CONTEXT: Agriculture plays a central role as a feedstock provider for the bioeconomy. However, utilization competing with food production and associated land use change have previously been a matter of debate. Nonetheless, strengthening the productivity of agroecosystems through sustainable intensification can prevent the depletion of natural resources, enhance food security, and facilitate adapta

Background: The number of pregnant women with congenital heart disease (CHD) is rising, and the disease poses increased risks of cardiovascular and obstetric complications during pregnancy, potentially impacting breastfeeding success. This study aimed to investigate breastfeeding in primiparous women with CHD compared to primiparous women without CHD, and to examine potential hindering factors for

BACKGROUND: Data on functional and psychological side effects following curative treatment for prostate cancer are lacking from large, contemporary, unselected, population-based cohorts. OBJECTIVE: To assess urinary symptoms, bowel disturbances, erectile dysfunction (ED), and quality of life (QoL) 12 mo after robot-assisted radical prostatectomy (RARP) and radiotherapy (RT) using patient-reported

BACKGROUND: Drug-resistant epilepsy (DRE) in selected individuals with the rare tuberous sclerosis complex (TSC) may benefit from resective epilepsy surgery. Furthermore, associated neuropsychiatric disorders (TAND) are common in patients with TSC; however, long-term data on how surgery affects neuropsychiatric comorbidities are sparse.MATERIALS AND METHODS: Two retrospective approaches were used

Different approaches have been used for translation of the EAT–Lancet reference diet into dietary scores that can be used to assess health and environmental impact. Our aim was to compare the different EAT–Lancet diet scores, and to estimate their associations with all-cause mortality, stroke incidence, and greenhouse gas emissions. We did a systematic review (PROSPERO, CRD42021286597) to identify

BACKGROUND AND OBJECTIVE: Prostate cancer (PC) and dementia may commonly co-occur; yet, prior evidence for bidirectional associations is inconsistent. This study aims to determine the associations between PC and dementia in large population-based studies, which may further inform clinical care. METHODS: To assess the dementia risk in men with PC, a national cohort study was conducted in 178 746 me

IMPORTANCE Risk stratification strategies in primary prevention of coronary events lack precision. OBJECTIVE To determine whether prediction of first coronary events is improved by adding information on coronary atherosclerosis from coronary computed tomography angiography (CCTA) to a model using the pooled cohort equation (PCE) risk score tool and the coronary artery calcification score (CACS). D

The textile industry generates vast wastewater containing synthetic dyes and polymeric additives like poly(vinyl alcohol) (PVA), which pose serious environmental challenges. Conventional treatment methods struggle to remove these contaminants while enabling resource recovery. PVA, widely used as a textile sizing agent, increases treatment complexity, while reactive dyes like Reactive Yellow 145 ar

Background: Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial changes and exposures may have a stronger impact than if they occurred during other time periods. This study aims to identify associations between ambient air pollution exposure during pregnancy and

Background: The clinical management of ER-positive/HER2-negative (ERpHER2n) breast cancer is complicated by a heterogeneous patient population, with some patients exhibiting endocrine resistance and an increased risk of recurrence. Among these high-risk subgroups, ERpHER2n Basal-like (ERpHER2n-Basal) breast cancer, as defined by PAM50 gene expression subtyping, remains poorly characterized due to

Syftet med studien är att undersöka hur bygg- och fastighetsbranschen arbetar med problematiken kring värmeböljor och höga inomhustemperaturer i bostäder. Målsättningen är att få förståelse för problematiken, utreda och bidra med kunskap inom ämnet för bostäder i befintligt bestånd respektive nyproduktion. Inledningsvis genomfördes en litteraturstudie vilken var ämnad att skapa en omfattande och The purpose of the study is to investigate how the construction and real estate industry work with the problems concerning heat waves and high indoor temperatures in housing. The objective is to obtain an understanding, to investigate and to contribute with knowledge of the problem for existing housing and for future housing. Initially, a literature study was conducted which was intended to creat

För att klara av den kommande demografiska utmaningen med en antagen fortsatt stigande medellivslängd, behöver arbetslivet förlängas. Då pensionen beräknas utifrån förväntad medellivslängd vid pensionering, kommer pensionen successivt bli allt lägre i förhållande till slutlönen om inte den ökade medellivslängden balanseras upp av en höjd utträdesålder från arbetslivet. Det finns ett flertal pensioIn order to cope with the coming demographic challenge with an assumed continued rising average life expectancy, working life needs to be extended. Since the pension is calculated on the basis of expected average life expectancy at retirement, the pension will gradually become lower in relation to the final salary unless the increased average life expectancy is compensated by an increased retireme

Yrkeslegitimationen inom hälso- och sjukvården anses utgöra en garanti för att den enskilde yrkesutövaren besitter den kompetens och de personliga egenskaper som krävs för yrket i fråga. En yrkesutövare (t.ex. en läkare) som inte bedöms vara lämplig för att få fortsätta sin yrkesutövning ska enligt 8 kap. 3 § patientsäkerhetslagen (2010:659), PSL, få sin legitimation återkallad av Hälso- och sjukvThere is a presumption that holding a professional license within the health care sector guarantees that the health care practitioner has the appropriate competence and personal qualities that are required for the specific medical profession. A health care practitioner (e.g. a medical doctor) who is no longer considered to be suitable to perform health and medical services shall, in accordance wit

Konsignation är ett handelsupplägg som i näringslivet främst används i avtalsrelationen mellan leverantörer och återförsäljare. Upplägget går ut på att leverantören, konsignanten, deponerar varor med bibehållen äganderätt för förvaring i ett varulager hos återförsäljaren, konsignatarien. Konsignatarien har därefter en rätt att göra uttag från lagret på kredit, som ofta sker i samband med vidareförConsignment is a form of trade arrangement most frequently used between suppliers and retailers. The point of the arrangement is that the supplier, the consignor, places goods with contained ownership for storage at the possession of the retailer, the consignee. The consignee then has a right to withdraw goods on credit, often in connection to the sale to a third party. The capability of the arran