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The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the resp
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Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine
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Hospital care is a joint production involving a wide range of services; ranging from medical services to support services to hotel services. This paper, focusing on the cooperation between these services, models the internal organization of public hospitals. The analysis is based on the property rights approach to organization (aka the Grossman-Hart-Moore model) and adopts it to the realities of p
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As multi-storey buildings with wooden framework are being build, constructors are faced with problems like, for instance, deformation of the wood, that is barely noticeable in a smaller house, but significant in larger buildings. Largest deformations of the wood occur w hen wood with a high original moisture content is loaded perpendicular to the grain and simultaneous allo w ed to dry, for instan
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The purpose of this master thesis is to investigate effects of warping and distortion in thin-walled box-girder bridges, see figure below. The master thesis deals with a number of different analytic methods, which are compared to finite element models. Transverse distortional bending moments and direct stresses, caused by torsional and distortional warping, is determined by analytic methods. Simpl