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Normal urine storage and bladder emptying are controlled by the central (CNS) as well as the peripheral nervous system. Dysfunction of these mechanisms can lead to urinary incontinence. Urinary tract dysfunctions have symptomatically been treated mainly with drugs acting peripherally. However, in the CNS, drug targets for pharmacological intervention may be found. The present study deals with effe

Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. The cell cycle is a closely controlled process, involving multiple components with regulation on several

Prostate cancer (PCa) is a heterogenous disease including very aggressive lethal tumors to incidentally discovered clinically insignificant tumors. Age, ethnicity, and family history are the only established risk factors. Type 2 diabetes mellitus (T2D) has been found to associate with increased overall cancer risk but with lower risk of specifically PCa. T2D is initially associated with increased

Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcript

This research programme focuses on Democracy and Public Administration, with an emphasis on making democratic institutions better fit to handle contested issues through the use of insights from Peace and Conflict Studies. We are interested in public administration’s role in addressing and (possibly) resolving contested issues and conflicts, in order to increase equality, strengthen processes of in

Differential expression of microRNAs (miRNAs) is observed in many diseases including type 2 diabetes (T2D). Insulin secretion from pancreatic beta cells is central for the regulation of blood glucose levels and failure to release enough insulin results in hyperglycemia and T2D. The importance in T2D pathogenesis of single miRNAs in beta cells has been described; however, to get the full picture, h

During inflammation, cellular glucose uptake and glycolysis are upregulated to meet an increased energy demand. For example, keratinocyte glycolysis is essential for progression of psoriasis. Therefore, understanding the regulation of glucose metabolism in keratinocytes is of importance. Here, we show that the pro-inflammatory cytokines IFNγ and TNF together rapidly induce glucose uptake, glycolys

Artistic research—research carried out by artists, through artistic practice—displays the markers of a burgeoning academic discipline. Dominant perspectives on research cultures would therefore predict that practitioners’ boundary work would play a decisive role in the development of this field. But when binary understandings come up against multiplex meanings, when and how do binaries matter? Foc

This special issue of Ethnologia Europaea explores new paths for our scientific disciplines within the expanding field of medical humanities. Medical humanities have seen a significant expansion in recent years, creating new research foci and leading to collaborations both within and outside of the humanities. As it is a growing academic field, we argue that it is necessary to be part of the medic

The article maps the pitfalls and affordances of automatic speech recognition in the study of audiovisual media and digital history more broadly. Three key topics are emphasized: first, the collaboration between scholars and audiovisual archives and the potential of automatic speech recognition to transform the way scholars navigate and engage with audiovisual media history; second, what knowledge

It has been known for decades that risk factors for diabetes and cardiovascular disease (CVD) tend to cluster. Metabolic syndrome refers to this risk factor clustering for some of the more well-established and dangerous risk factors. This chapter provides a historical overview on the concept of the metabolic syndrome; describes the clinical criteria used in the definition of the metabolic syndrome

Glucagon has long been defined by its glucogenic action and as a result α-cells have been characterised based largely on their interaction with glucose. Recent findings have challenged this preconception, bringing to the fore the significant role glucagon plays in amino acid breakdown and underlining the importance of amino acids in glucagon secretion. The challenge that remains is defining the me