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Computer generated imagery is vital to the entertainment industry in the production of games and films, for example. It is also increasingly important for visualization in design, architecture, engineering, and medicine, to name a few. Improvements to rendering techniques come from a combination of improved algorithms and more powerful hardware. Typically, hardware developments introduce new chall
In light of autobiographical theory, this study deals with the critics' reception of Simone de Beauvoir's La Force des choses when the book was first published in 1963 in France. The three main parts examine the critical comments on the genre, the final controversial words expressing the author's disappointment, and the evaluation of her style. For the latter, Morten Nøjgaard's theory of literary
In the hippocampus, dendritic spines are compartmentalized postsynaptic micro-domains in the excitatory synapse. Subsets of bigger and mushroom-shaped hippocampal dendritic spines contain tubules and cisterns of endoplasmic reticulum (ER) that are connected to the soma and dendrites of the neuron. These ER containing spines differ in their ability to retain ER. We hypothesized a functional couplin
Diabetes affects around 200 million people worldwide. Curing diabetes would require the prevention of autoimmune destruction of beta cells and restoration of the beta cell mass restored either through regeneration or transplantation of the insulin producing cells. Islet transplantation according to the Edmonton protocol have been the most promising therapeutic option for Diabetes type I patients,
Fast and reliable data transmission together with high bandwidth efficiency are important design aspects in a modern digital communication system. Many different approaches exist but in this thesis bandwidth efficiency is obtained by increasing the data transmission rate with the faster-than-Nyquist (FTN) framework while keeping a fixed power spectral density (PSD). In FTN consecutive information
Identification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. The porcine eye has a typical primate-like architecture and is similar to the hum
Throughout its history Earth experienced a variety of natural climate changes. By investigating their spatial and temporal evolution we can increase the understanding of the mechanisms and dynamics underlying natural climate change and improve our general comprehension of the climate system. Prerequisites of these investigations are reliable reconstructions of past forcing variations as well as so
Cellular reprogramming is when one cell is changed into another. This involves structural modifications on the DNA of a cell resulting in a transcriptional change. This occurs naturally during development when early pluripotent cells gradually differentiate into more specialized cells that finally result in a complete organism. This is a finely orchestrated event that includes both extrinsic and i
The first part of this thesis deals with approximations of stochastic integrals and discrete time hedging of derivative contracts; two closely related subjects. Paper A considers the problem of approximating the value of a Wiener process. The discretization points are placed at times when the absolute difference between the value of the process and the approximation reaches a threshold level. It i
As a special part of our cultural heritage, toponyms have been handed down orally from generation to generation for centuries or more at the place where they were coined, recalling events, activities and knowledge. Especially where written documentation is relatively young, place names offer a way to reach further back into the past. This is particularly true of many dialectal cultures, in which o
The majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. Elevated expression of a cell cycle regulator cyclin A1 initiated leukemia
Paper I: Perfekt, K.-M. and Putinar, M., Spectral bounds for the Neumann-Poincaré operator on planar domains with corners, to appear in J. Anal. Math., (2012). The boundary double layer potential, or the Neumann-Poincaré operator, is studied on the Sobolev space of order $1/2$ along the boundary, coinciding with the space of charges giving rise to double layer potentials with finite energy in the
Assessment of the right side of the heart is important in patients with heart disease; especially in patient with elevated pressure in the lung circulation. Decreased right ventricular function and elevated pressure in the right atrium are of poor prognostic value. Two-dimensional echocardiography (ultrasound of the heart) is the most commonly used method to assess the hearts function, but the rig
Breast cancer is the most common form of cancer affecting women in the western countries. Today x-ray digital mammography (DM) of the breast is commonly used for early detection of breast cancer. However, the sensitivity of mammography is limited, mainly due to the fact that a 3D volume is projected down to a 2D image. This problem can be partially solved by a tomographic technique. Breast tomosyn
Laser-driven particle acceleration makes use of sub-picosecond, pulsed, high-power laser systems, capable of producing intensities ~10^{19} W/cm^2 at the laser focus to form plasmas, and use ultra-relativistic and nonlinear dynamics to produce quasistatic acceleration fields. This allows electrons to be accelerated to ~100 MeV over sub-centimetre distances, while protons may be accelerated to the
Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. The hypothalamus has emerged as an
Human adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. The cancer cell killing capacity of oncolytic Ad is
Märta Måås-Fjetterström’s textile career was largely based on a collective effort. As a textile artist in her own workshop, she drew patterns that she let employed weavers weave. Together with a few other artists, she helped elevate the craft – the carpet – to the realm of art, by signing her works early on. After Märta Måås-Fjetterström’s death, Barbro Nilsson took over the role as artistic direc
Extreme heat and heatwaves constitute a growing challenge för municipal planning in relation to climate change. The aim of this study is to examine how risks related to extreme heat are addressed in the comprehensive planning of Malmö, Landskrona and Hässleholm, and also see how these approaches can be understood in relation to urban resilience and the PCCC framework created by Jabareen (2015) - P
Cerebral visual impairment (CVI) is a brain-based neurodevelopmental disorder of visual processing caused by early injury to visual pathways and cortical areas. Visual processing relies on two anatomically and functionally distinct pathways originating in the primary visual cortex (V1): the dorsal ("where") stream, which processes spatial location, and the ventral ("what") stre
