Inflammation and ischemia have a synergistic damaging effect in the immature brain. The role of tumor necrosis factor (TNF) receptors 1 and 2 in lipopolysaccharide (LPS)-induced sensitization and tolerance to oxygen-glucose deprivation (OGD) was evaluated in neonatal murine hippocampal organotypic slices. Hippocampal slices from balb/c, C57BL/6 TNFR1(-/-), TNFR2(-/-), and wild-type (WT) mice obtai

Loneliness in advanced age has become one of the societal concerns considering its detrimental effects on physical and mental health of older people. Information and communication technologies show the potential to prevent or tackle loneliness and social isolation among older people. Given a percentage of the older population feeling lonely, loneliness in older age has been increasingly recognized

Building information modeling (BIM) and building energy modeling (BEM) are two key tools to make the transition to net-zero energy buildings (NZEB). However, a recent literature review indicated that the conversion from BIM to BEM is currently dysfunctional, due to limitations regarding competencies, processes, and technology. In this article, a case study is presented to show how the information

We investigate the occurrence of water vapour signatures in a total of 10 red giants in the solar neighbourhood at mid-infrared wavelengths (12 pm). With the use of high resolution spectra from TEXES and synthesized spectra based on MARCS model atmospheres, we analyse the differences and discuss plausible causes. These include abundance adjustments, the addition of non-photospheric components (MOL

Popular Abstract in Swedish Ärftlig brist på vissa proteiner ökar risken för autoimmun sjukdom eller svår hjärnhinneinflammation I blodbanan finns ett 30-tal olika proteiner som ingår i den del av vårt immunförsvar som kallas komplementsystemet. Detta systems huvudsakliga uppgifter är att förinta oönskade inkräktare, såsom bakterier och virus, samt eliminera skadliga proteinkomplex som cirkulerarComplement deficiency is associated with an increased risk for invasive infection and immune complex disease. Screening for identification of complement-deficient patients is essential and a new ELISA-based procedure for detection of complement deficiency is described. Molecular characterization of a complete C4 deficiency and of three phenotypic forms of properdin deficiency is also reported. The

Self-tuning control of the dissolved oxygen concentration has been tested in full scale at the Käppala Sewage Works at Lidingö, Sweden. The controller has been shown to be robust during varying operating conditions. It also gives the potential for the estimation of interesting variables, such as the oxygen uptake rate. A number of water quality variables have been examined. Interesting couplings b

A quarter of DA white dwarfs are metal polluted, yet elements heavier than helium sink down through the stellar atmosphere on time-scales of days. Hence, these white dwarfs must be the currently accreting material containing heavy elements. Here we consider whether the scattering of comets or asteroids from an outer planetary system, following stellar mass-loss on the asymptotic giant branch, can

Increased production of autoantibodies is a characteristic feature of systemic lupus erythematosus (SLE) and there is evidence that several of these autoantibodies may contribute to the increased cardiovascular disease (CVD) in SLE. Autoantibodies against the apolipoprotein (apo) B-100 peptides p45 and p210 have been associated with a lower CVD risk in non-SLE cohorts. The aim of the present study

In this paper we study the interaction between starch which has been hydrophobically modified, with octenyl succinic anhydride (OSA), and alpha-beta-livetin, which is the water soluble fraction of egg yolk. The modification of the starch renders it surface active and also incorporates a carboxyl group to the starch, which can be negatively charged. The interaction was studied both in solution and

Laser-induced fluorescence is a technique for optical tissue characterisation. It has a real-time capability and as the excitation light and the fluorescence emission are transmitted through optical fibres the technique is compatible to various kinds of endoscopes for hollow organ investigation. The tissue fluorescence itself with the emission from the endogenous chromophores or enhanced with exog

OBJECTIVES: Neutrophils are activated and infiltrate the myocardium after ischemia and reperfusion. The involvement of neutrophils in irreversible reperfusion injury is suggested by numerous experimental studies. The aim of this study was to investigate markers of neutrophil activation following reperfusion of acute myocardial infarction (AMI) accomplished with percutaneous coronary intervention (

The scientific community has gratefully embraced floating-point arithmetic to escape the close attention for accuracy and precision required in fixed-point computational styles. Though its deficiencies are well known, the role of the floating-point system as standard has kept other number representation systems from coming into practice. The paper discusses the relation between fixed and floating-

Rapid elasticity is one of the essential characteristics of cloud computing identified by NIST [17]. Elasticity allows resources to be provisioned and released to scale rapidly out ward and in ward according to demand. Tens - if not hundreds - of algorithms have been proposed in the literature to automatically achieve elastic provisioning [15, 23, 14, 21, 13, 20, 6, 12, 16, 10]. These algorithms a

Increasing interdependencies between critical infrastructures have made these systems more effective, but also more susceptible to cascading failures. In order to reduce the likelihood and consequences of cascading failures, it is essential to develop tools that support incident commander decisions so that an initial failure does not spread to other infrastructures. Here, a framework for generatin

BACKGROUND: Different adiposity traits may be causally related to hypertension in different ways. By using genetic variants as randomly allocated proxies for studying the effect of modifying adiposity traits, the Mendelian randomization approach can be used to investigate this. METHODS AND RESULTS: In this study, we used 4 different genetic risk scores (GRS; GRS-BMI 565, GRS-WHR 324, GRS-VAT 208,

This paper presents an alternative workflow for thermal comfort prediction. By using the leverage of Data Science & AI in combination with the power of computational design, the proposed methodology exploits the extensive comfort data provided by the ASHRAE Global Thermal Comfort Database II to generate more customised comfort prediction models. These models consider additional, often signific