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The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. Dystroglycan is a receptor for multiple extracellular matrix (ECM) molecules such as Laminin, agrin and perlecan, and plays a role in linking the ECM to the actin cytoskeleton; however, how these interactions are r
Knowledge in statistics is essential to draw solid conclusions from data. This chapter covers the basic concepts needed to navigate in the world of biostatistics, with the aim that the reader should know what to search for when encountering new situations. First, the chapter introduces basic concepts such as scales of measurement, relation between sample and population, and features of stochastic
Introduction: Housing shortage due to population growth within metropolitan areas, combined with an ageing population, has put pressure on current housing provision in Sweden. Thus, there is an urgent need to develop sustainable housing policies to accommodate the growing number of seniors in accessible home environments. This study aimed to gain an in-depth understanding of how municipalities cur
Population ageing means that increasingly many are faced with the dual demands of paid work while providing unpaid care to older family members. Caregiving requires time and energy, with implications for paid work and well-being. The challenges faced by individuals add up and therefore also impact national economies. This dissertation provides insights into the implications of unpaid caregiving fo
AimTo analyze the impact of a time-gain selective, first-responder dispatch system on the presence of a shockable initial rhythm (SIR), return of spontaneous circulation (ROSC) and 30-day survival after out-of-hospital cardiac arrest (OHCA).MethodA retrospective observational study comprising OHCA registry data and dispatch data in the Skåne Region, Sweden (2010–2018). Data were categorized accord
Audio description (AD) offers people with visual impairments and blindness a richer and more detailed understanding and experience of film, theatre and other events by describing what is seen but not heard (Holsanova 2016b, 2020a). With the analysis of audio described film scenes, I will illustrate that AD is a complex meaning-making activity that cannot be limited to only replacing the visual par
Lung cancer (LC) generally lacks unique core symptoms or signs. However, there are a multitude of bodily sensations that are often non-specific, not easily understood, and many times initially not recognized as indicative of LC by the affected person, which often leads to late diagnosis. In this international qualitative study, we inductively analyzed retrospective accounts of 61 people diagnosed
Many studies have used the relative activities of extracellular enzymes associated with microbial carbon (C), nitrogen (N) and phosphorus (P) acquisition to infer the relative C vs. nutrient limitation of the microbial community. However, recent experimental and theoretical evidence has shown that the use of ecoenzymatic ratio to infer limiting microbial resources may be invalid. We added the two
