Search results

Variation of the blood content of the pulmonary vascular bed during a heartbeat can be quantified by pulmonary blood volume variation (PBVV) using magnetic resonance imaging (MRI). The aim was to evaluate if PBVV differs in patients with heart failure compared to healthy controls and investigate the mechanisms behind the PBVV. Forty-six patients and 10 controls underwent MRI. PBVV was calculated f

Introduction: The use of medications in the general population has increased over time. Information on active metabolite concentrations for common drugs in the general population is limited. Recent advances in metabolomic technologies have made high-throughput profiling of many active metabolites in large epidemiological cohorts increasingly feasible.Aim: 1. Prospective assessment of the proportio

The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. Here, we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 tran

Introduction: Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and type 2 diabetes (T2D). No cure for DPN is available, but several potential targets have been proposed for treatment. Heat shock proteins (HSPs) are known to respond to both hyper- and hypoglycemia. DPN can be diagnosed using electrophysiology and studied using peripheral nerve biopsies.Aim: This st

Nanoplastics have been proven to induce toxicity in diverse organisms, yet their effect on soil microbes like bacteria and fungi remains largely unexplored. In this paper, we used micro-engineered soil models to investigate the effect of polystyrene (PS) nanospheres on Pseudomonas putida and Coprinopsis cinerea. Specifically, we explored the effects of increasing concentrations of 60 nm carboxylat

The great variety of earth's microorganisms and their functions are attributed to the heterogeneity of their habitats, but our understanding of the impact of this heterogeneity on microbes is limited at the microscale. In this study, we tested how a gradient of spatial habitat complexity in the form of fractal mazes influenced the growth, substrate degradation, and interactions of the bacterial st

Stem cell therapies for Parkinson's disease are at an exciting time of development, and several clinical trials have recently been initiated. Human pluripotent stem cells are differentiated into transplantable dopamine (DA) progenitors which are proliferative at the time of grafting and undergo terminal differentiation and maturation in vivo. While the progenitors are homogeneous at the time of tr

Introduction: The role of the complement inhibitory proteins CD46 and CD59 in the immune response to an acute coronary syndrome (ACS) is unknown. We investigated the relationships between the shedding of CD46 and CD59 into the circulation, reflected by plasma levels of soluble CD46 and CD59, and the risk for post-ACS complications. Methods: We measured plasma sCD46 and sCD59 in a cohort of 546 ACS

Toxicological testing in mice was conducted on PM2.5 particles from stressed burning of two types of candles (white and blue) and on PM2.5 collected indoor and outdoor of fifteen occupied homes in southern Sweden. As an indicator of toxicity, the ability to generate Reactive Oxygen Species (ROS) was also assessed for all pooled samples: candle white, candle blue, indoor, and outdoor. Higher toxici

• We aimed to capture possible insights from an AI diagnosing without human guidance.• We believe the result mainly aligns with previous knowledge. Though, vital signs and sex did not aid the AI diagnostics.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder involving scarring of pulmonary tissue and a subsequent decrease in respiratory capacity, ultimately resulting in death. Tartrate resistant acid phosphatase 5 (ACP5) plays a role in IPF but the exact mechanisms are yet to be elucidated. In this study, we have utilized various perturbations of the bleomycin mouse model of IPF includ

We report a new design of an acoustophoretic trapping device with significantly increased capacity and throughput, compared to current commercial acoustic trapping systems. Acoustic trapping enables nanoparticle and extracellular vesicle (EV) enrichment without ultracentrifugation. Current commercial acoustic trapping technology uses an acoustic single-node resonance and typically operates at flow

Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor microenvironment. Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as t

Microsoft Word - Baskompetenser timanställda med yttre tjänst, FINAL 170918_180219.docx Baskompetenser timanställda med yttre tjänst 1. Lunds Universitet o Ha övergripande kännedom om Lunds universitet: strategi och organisation, inkluderat hur LUB:s nätverksorganisation ser ut och fungerar. o Kunna hänvisa till information på lu.se. o Känna till var man kan hämta ut LU-kort, samt kunna hänvisa ti

https://www.lub.lu.se/internt/sites/lub.lu.se.internt/files/baskompetenser_timanstallda_med_yttre_tjanst_final_170918_180219.pdf - 2026-01-08

Ansökan om tillgodoräknande av hel kurs eller del av kurs Ange nedan vilken kurs som du önskar ersätta. Gäller det del av kurs, ange momentet/provkoden. Gäller det termin 5 i kandidatprogrammen, skriv Valbar kurs. Kurskod Kursens namn Antal hp Ange nedan den eller de kurser du vill åberopa (som du har läst tidigare). Gäller det del av kurs, ange momentet/provkoden. Kurskod Kursens namn Lärosäte An

https://www.isk.lu.se/sites/isk.lu.se/files/tillgodoraknande_blankett_10.pdf - 2026-01-08

9 maj 2025 16:00 till 18:00 | Övrigt HÅLL(BAR) - Hållbarhetsveckans mötesplats och AW gästas i år av Ida Persson och Peter Bentzer från organisationen Läkare för miljön Skåne. De kommer att berätta om sitt miljöengagemang inom sina professioner som läkare på Region Skåne och om hälso- och sjukvårdens roll i klimatomställningen. Välkommen till HÅLL(BAR)! Lunds mötesplats och AW för hållbarhetsvecka

https://www.medarbetarwebben.lu.se/evenemang/hallbar-aw-miljoengagemang-pa-arbetsplatsen-med-lakare-miljon-skane - 2026-01-08