The brain tissue has only a limited capacity for generating new neurons. Therefore, to treat neurological diseases, there is a need of other cell sources for brain repair. Different sources of cells have been subject of intense research over the years, including cells from primary tissue, stem cell-derived cells and reprogrammed cells. As an alternative, direct reprogramming of resident brain cell

Second-generation fuel ethanol is typically researched using one type of raw material as feedstock. However, the variability in the supply and quality of biomass calls for an expansion of the feedstock base to ensure sufficient supply for commercial-scale production. By expanding the feedstock base and using mixtures in the conversion process, the biomass supply can be improved and associated econ

Calculations of excited-state potential energy surfaces (PESs) are useful to predict key properties relating to the deactivation cascade of transition-metal complexes. Here, we first perform full free optimizations of the relevant excited-state minima, followed by extensive two-dimensional PES calculations based on the minima of interest. Maps of the lowest triplet excited-state surfaces of two bi

Purpose: To describe how patients with acute/subacute back pain and/or neck pain experienced a workplace intervention, conducted as a structured workplace dialogue (convergence dialogue meeting, CDM) within physiotherapy practice in primary care. Materials and methods: Semi-structured interviews were performed with 10 patients who took part in the CDM. Qualitative content analysis was applied to t

As a new type of fin structure in finned tube heat exchangers, dimple turbulators exhibit excellent potential for thermo-hydraulic performance enhancement. A three-dimensional numerical simulation study was conducted to investigate the influences of five kinds of innovative concave dimple turbulators (CDTs), namely–elliptical dimple, conical frustum dimple, trapezoidal prism dimple, leeward triang

Objective: The objective of this study was to compare short-term outcomes in patients who underwent thoracic endovascular aortic repair (TEVAR) with stent grafts alone or with a composite device design (stent graft plus bare-metal aortic stent) for acute type B aortic dissection in the setting of malperfusion. Methods: This retrospective analysis included patients with acute (≤14 days of symptom o

Background: When a relative with a critical illness is admitted to an intensive care unit (ICU), it can be a life-changing event for the partner. There is a lack of studies that focus on the partners' experiences of the time after intensive care. Aims and objectives: The aim of this study was to explore the experiences of partners of intensive care survivors and their need for support after intens

In view of the current situation of single form and low efficiency, a coaxial mixer with wide adaptability was combined with the drawdown of floating particles in viscous systems, and the effects of operation mode, impeller type, impeller diameter, impeller submergence, system viscosity, solid concentration and particle size were investigated experimentally. It is found that the coaxial mixer unde

This paper introduces a new experimental method to monitor the evolving intra-particle, nanometre-scale response during hydro-mechanical tests on undisturbed wet clay samples using small angle X-ray scattering (SAXS). The method uses a newly developed miniature plane-strain one-dimensional compression cell that facilitates simultaneous full-field surface displacement measurements using digital ima

The valorization of lignin is being increasingly recognized as crucial to improve the economic viability of integrated biorefineries. Because of its inherent heterogeneity and recalcitrance, lignin has been treated as a waste product in the pulp and paper industry, but new technologies are now being explored to transform lignin into a sustainable resource and enhance its value chain. In the presen

Air travel is predicted to grow over the coming decades contributing to carbon emissions. Airlines have offered voluntary carbon offsetting for over a decade, yet less than 10% of air travellers purchase them. Previous studies ignore the broader policy or social context of sustainable transport and aviation offsetting. In a natural experiment, a panel of the same Australian residents was tracked o

The transmittance properties of the cornea, lens and humours of vertebrates determine how much light across the visible spectrum reaches the retina, influencing sensitivity to visual stimuli. Amphibians are the only vertebrate class in which the light transmittance of these ocular media has not been thoroughly characterised, preventing large-scale comparative studies and precise quantification of

Objective: To study chronic widespread pain (CWP) over time in patients with spondyloarthritis (SpA), and to identify risk factors for development and persistence of CWP. Methods: In this cohort study with baseline and 2.5 year follow-up postal surveys, patients with ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (USpA) (47% women) answered questions regarding pain, and were ca

Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration. Dysregulation of the Hippo pathway has been recognized in a variety of human cancers, including pancreatic cancer. YES-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the two major downstream effectors of the Hippo pathway. YAP and TAZ have been found to promote pancreati

While scholars commonly assume that Global Governance Institutions (GGIs) need legitimacy to perform effectively, there are few systematic empirical studies assessing the consequences of legitimacy (or the lack thereof) for the functioning of GGIs. Inspired by the new institutionalism in organization theory, which predicts that more legitimate organizations will get more resources than illegitimat

The existing information supports the use of this material as described in this safety assessment. Methyl 2-nonenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog ethyl trans-2,cis-4-decadienoate (CAS # 3025-30-7) show that methy

Background: Although women with fear of birth often report negative birth experiences, few studies have focused on their experiences in the long term. The aim of this study was to compare birth experiences a year after childbirth in two groups of women receiving treatment for experiencing fear of birth during pregnancy. Methods: As part of the U-CARE: Pregnancy Trial, a prospective multicenter ran