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Cardiovascular events in elderly patients with isolated systolic hypertension. A subgroup analysis of treatment strategies in STOP-Hypertension-2.
Adsorption of intact methanol on Ru(0001)
Fourier transform infrared absorption spectroscopy has been used to study the adsorption of methanol on the clean Ru(0001) surface at T <= 80 K. Thereby, clear evidence for intact adsorption has been found. This observation contradicts previous studies which suggested an OH(OD) bond scission upon adsorption of methanol on Ru(0001), even at low temperatures, as well as partial recombinative desorpt
A comparison of two feedforward control structure assessment methods
The most common loop in an industrial plant is a SISO-loop with a PI(D)controller. If the loop is affected by disturbances,these can be handled by adding a feedforward control action. In an industrial control system there are many measured signals, apart from those of the loop, available. The question we address in this article is how to select the feedforward variable out of the available measure
Effects of enrichment on simple aquatic food webs
Simple models, based on Lotka-Volterra types of interactions between predator and prey, predict that enrichment will have a destabilizing effect on populations and that equilibrium population densities will change at the top trophic level and every second level below. We experimentally tested these predictions in three aquatic food web configurations subjected to either high or low nutrient additi
Bioavailability and sources of DOC and DON in macrophyte stands of a tropical coastal lake
Dissolved organic carbon (DOC) and nitrogen (DON) derived from aquatic and terrestrial vascular plants provide a major energy and nutrient source for freshwater and coastal marine biota. The bioavailability of this material may to a large extent depend on plant species. In this study, we have compared the bioavailability of DOC and DON sampled in two distinct stands of Typha domingensis and Eleoch
Monte Carlo simulations of polyelectrolytes inside viral capsids
Structural features of polyelectrolytes as single-stranded RNA or double-stranded DNA confined inside viral capsids and the thermodynamics of the encapsidation of the polyelectrolyte into the viral capsid have been examined for various polyelectrolyte lengths by using a coarse-grained model solved by Monte Carlo simulations. The capsid was modeled as a spherical shell with embedded charges and the
Concentrations of 60 elements in the soil solution as related to the soil acidity
Little is known about solubility and soil solution concentrations of most elements occurring in the solid phase of soils. This study reports changes in solution concentrations of 60 mineral elements following CaCO3 addition to a moderately acid semi-natural soil, and possible mechanisms accounting for the differing solubility patterns as related to soil acidity are discussed. Soil solutions were o
The nutritional quality of an infant food from quinoa and its effect on the plasma level of insulin-like growth factor-1 (IGF-1) in undernourished children.
An infant food product was manufactured by drum drying a pre-cooked slurry of quinoa (Chenopodium quinoa, Willd) flour. The chemical composition shows that the product is a potential source of valuable nutrients, like protein (16%), vitamin E (19 mg/kg), thiamine (0.7 mg/100 g), iron (70 mg/kg), zinc (48 mg/kg) and magnesium (1.8 g/kg), all the values expressed on dry basis, to pre-school children
Attenuation of endothelium-dependent relaxation in rat mesenteric arteries by ApoB protein of low density lipoprotein, but not cholesterol
WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases
The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P) H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to
Synthesis and transfection efficiencies of new lipophilic polyamines
A homologous series of lipophilic polyamines was synthesized and evaluated for DNA delivery and transfection efficiency. The series contained 1,4-butanediamine, 1,8-octanediamine, 2-[2-(2-amino-ethoxy)-ethoxy]-ethylamine, homospermidine, and homospermine covalently attached via their N-1 terminus to a 3,4-bis(oleyloxy)-benzyl motif. In addition, homospermidine and homospermine were also attached v
Decoherence and current fluctuations in tunneling through coupled quantum dots
The electronic transport through two coupled quantum dots in series can be described either in a fully coherent approach (e.g. density matrix description or nonequilibrium Green's functions) or in a simple sequential tunneling treatment (Pauli master equation with Fermi's Golden rule for coupling between the quantum dots). It turns out that both descriptions provide the same average current for no
Dispersion of atrial repolarization in patients with paroxysmal atrial fibrillation
To study the role of the dispersion of atrial repolarization (DAR) in the genesis of atrial fibrillation (AF), monophasic action potentials (MAP) were recorded simultaneously from a catheter at the high lateral right atrium (HLRA) and a catheter moving around the high, middle and low lateral right atrium (RA) the high, anterior and posterior septal RA and the RA appendage in 15 patients with parox
The human cathelicidin hCAP-18
Redox signalling in chloroplasts and mitochondria: genomic and biochemical evidence for two-component regulatory systems in bioenergetic organelles
Redox chemistry is central to the primary functions of chloroplasts and mitochondria, that is, to energy conversion in photosynthesis and respiration. However, these bioenergetic organelles always contain very small, specialized genetic systems, relics of their bacterial origin. At huge cost, organellar genomes contain, typically, a mere 0.1% of the genetic information in a eukaryotic cell. There
Challenges Associated with Scaling up Artemisinin Combination Therapy in Sub-Saharan Africa A Review Article
Malaria is the leading cause of morbidity and mortality in Sub-Saharan Africa. One key strategic intervention is provision of early diagnosis and prompt effective treatment. A major setback has been the development of drug resistance to commonly used antimalarials. To overcome this, most countries in Sub-Saharan Africa have adopted Artemisinin Combination Therapy (ACT) as a first line treatment fo
A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking
Sulfotransferase 1A1, an important member of sulfotransferase superfamily, is involved in the biotransformation of many compounds including tobacco carcinogens. A single nucleotide polymorphism (G638A) in the sulfotransferase 1A1 (SULT1A1) gene causes Arg213His amino acid change and consequently results in significantly reduced enzyme activity and thermostability. We thus hypothesized that the var
Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells.
Some strains of the human pathogen Streptococcus pyogenes express a surface protein called protein H, which is released from the streptococcal surface by a cysteine proteinase produced by the bacteria. Here, we find that soluble protein H binds to the surface of lymphocytes and granulocytes, and that the molecule is taken up by lymphocytes and transported to the perinuclear region. The translocati
The influence of fat stores on magnetic orientation in day-migrating Chaffinch, Fringilla coelebs
Earlier experimental studies have demonstrated the ability of day-migrating birds to perform migration under overcast skies, thereby indicating use of cues other than solar. The orientation behaviour of the chaffinch, a diurnal migrant, was investigated in orientation cage experiments during the autumn migration period. The aim of our experiments was to examine the relationship between different o
