Matrix metalloproteinase-26 (MMP-26) and Tissue inhibitor of metalloproteinases-4 (TIMP-4) in normal, hyperplastic, and malignant endometrium.
Popular Abstract in Swedish I avhandlingen studeras Matrix MetalloProteinase-26 (MMP-26) och Tissue Inhibitor of MetalloProteinases-4 (TIMP-4) i normalt, hyperplastiskt och malignt endometrium. Just detta protease/hämmarpar kan potentiellt vara av mycket stort intresse vid implantationsprocessen. Trofoblastvävnad från såväl humant som murint embryo producerar proMMP-9. Aktivt MMP-9 (Gelatinase B)The aim of the thesis was to study matrix metalloproteinase-26 (MMP-26) and tissue inhibitor of metalloproteinases-4 (TIMP-4) in normal, hyperplastic, and malignant endometrium. Most importantnly, both these molecules may be ivolved in the implantation process. Trophoblast tissue from human as well as mouse embryos produces pro-MMP-9. Active MMP-9 (gelatinase B) is a proteolytic enzyme with a bro